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Yusuf Hamied Department of Chemistry

 

We are interested in molecular recognition, aiming to uncover and exploit the rules governing non-covalent interactions. Hydrophobic, π–π, donor–acceptor, metal– ligand and hydrogen bonding interactions are used to create new supramolecular systems that expand our understanding of molecular behaviour and may have useful recognition, catalytic or photophysical properties. In particular in the past few years we have developed the concept of dynamic combinatorial chemistry as a new approach for discovering entirely unexpected structures and assemblies. Over the years our building blocks have included peptides, metalloporphyrins, steroids and simple aromatics, and our products have included macrocycles, rotaxanes, catenanes, molecular knots and supramolecular nanotubes. Very recently, while investigating dynamic chemistry in the solid state using ball mill grinding, we have discovered solvent and surface effects on polymorph stability in nanocrystals

Please note that I am not taking any new students or postdocs into my research group.

 

 

 

Selected Publications

 

Evolution of dynamic combinatorial chemistry, Accounts Chem. Res., (2012), 45, 2211.

Discovery of an organic trefoil knot, Science, (2012), 338, 783.

Templated dynamic synthesis of a [3]Catenane, Angew. Chemie Intl. Edn., (2012), 51, 1443.

Thermodynamics of supramolecular naphthalenediimide nanotubes, J. Am. Chem. Soc., (2012), 134, 566.

Discovery of linear receptors for multiple dihydrogen phosphate ions using dynamic combinatorial chemistry, J. Am. Chem. Soc., (2011), 133, 3804.

Formation pathways of Donor-Acceptor catenanes in aqueous dynamic combinatorial libraries, J. Am. Chem. Soc., (2011), 133, 3198.

Solid-state dynamic combinatorial chemistry, Chem. Sci., (2011), 2, 696.

An unexpected receptor for C70, Angew. Chemie Intl. Edn., (2008), 47, 2689.

Publications

The roles of templates in the syntheses of porphyrin oligomers
S ANDERSON, HL ANDERSON, JKM SANDERS
– Journal of the Chemical Society, Perkin Transactions 1
(1995)
2255
A platinum-linked porphyrin trimer and a complementary aluminium tris[3-(4-pyridyl)acetylacetonate] guest
LG MACKAY, HL ANDERSON, JKM SANDERS
– Journal of the Chemical Society, Perkin Transactions 1
(1995)
2269
Template-directed synthesis of linear and cyclic butadiyne-linked porphyrin oligomers up to a linear octamer
S ANDERSON, HL ANDERSON, JKM SANDERS
– J CHEM SOC PERK T 1
(1995)
2247
Ligand binding by butadiyne-linked porphyrin dimers, trimers and tetramers
HL ANDERSON, S ANDERSON, JKM SANDERS
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1995)
2231
Modelling the influence of porphyrin supermacrocycles on the kinetics of bimolecular reactions
RS WYLIE, JKM SANDERS
– Tetrahedron
(1995)
51,
513
Octatetrayne-linked porphyrins: 'Stretched' cyclic dimers and trimers with very spacious cavities
HL ANDERSON, CJ WALTER, A VIDALFERRAN, RA HAY, PA LOWDEN, JKM SANDERS
– J CHEM SOC PERK T 1
(1995)
2275
NMR study of whole rat bile: the biliary excretion of 4-cyano-N,N-dimethyl aniline by an isolated perfused rat liver and a liver in situ
DA Ryan, JK Sanders, GC Curtis, H Hughes
– Journal of pharmaceutical and biomedical analysis
(1995)
13,
735
NMR study of whole rat bile: the biliary excretion of cefoperazone and benzyl chloride by an isolated perfused rat liver
DA Ryan, JK Sanders, GC Curtis, H Hughes
– J Pharm Biomed Anal
(1995)
13,
723
Biomimetic, amorphous granules of polyhydroxyalkanoates: composition, mobility, and stabilization in vitro by proteins
DM HOROWITZ, JKM SANDERS
– Canadian Journal of Microbiology
(1995)
41,
115
Enzyme mimics
JKM SANDERS
– Proceedings of the Indian Academy of Sciences - Chemical Sciences
(1994)
106,
983
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Research Group

Research Interest Groups

Telephone number

01223 336411

Email address

jkms@cam.ac.uk