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Yusuf Hamied Department of Chemistry

 

We are interested in molecular recognition, aiming to uncover and exploit the rules governing non-covalent interactions. Hydrophobic, π–π, donor–acceptor, metal– ligand and hydrogen bonding interactions are used to create new supramolecular systems that expand our understanding of molecular behaviour and may have useful recognition, catalytic or photophysical properties. In particular in the past few years we have developed the concept of dynamic combinatorial chemistry as a new approach for discovering entirely unexpected structures and assemblies. Over the years our building blocks have included peptides, metalloporphyrins, steroids and simple aromatics, and our products have included macrocycles, rotaxanes, catenanes, molecular knots and supramolecular nanotubes. Very recently, while investigating dynamic chemistry in the solid state using ball mill grinding, we have discovered solvent and surface effects on polymorph stability in nanocrystals

Please note that I am not taking any new students or postdocs into my research group.

 

 

 

Selected Publications

 

Evolution of dynamic combinatorial chemistry, Accounts Chem. Res., (2012), 45, 2211.

Discovery of an organic trefoil knot, Science, (2012), 338, 783.

Templated dynamic synthesis of a [3]Catenane, Angew. Chemie Intl. Edn., (2012), 51, 1443.

Thermodynamics of supramolecular naphthalenediimide nanotubes, J. Am. Chem. Soc., (2012), 134, 566.

Discovery of linear receptors for multiple dihydrogen phosphate ions using dynamic combinatorial chemistry, J. Am. Chem. Soc., (2011), 133, 3804.

Formation pathways of Donor-Acceptor catenanes in aqueous dynamic combinatorial libraries, J. Am. Chem. Soc., (2011), 133, 3198.

Solid-state dynamic combinatorial chemistry, Chem. Sci., (2011), 2, 696.

An unexpected receptor for C70, Angew. Chemie Intl. Edn., (2008), 47, 2689.

Publications

Novel paper titles [8]
J Sanders
– Nature
(1997)
386,
114
A pharmacologically active derivative of tetrodotoxin
RY Tsien, DP Green, SR Levinson, B Rudy, JK Sanders
– Proceedings of the Royal Society of London. Series B. Biological Sciences
(1997)
191,
555
Selection approaches to catalytic systems
PA Brady, JKM Sanders
– Chemical Society Reviews
(1997)
26,
327
The elasticity of spiders' webs is due to water-induced mobility at a molecular level
KM BONTHRONE, F VOLLRATH, BK HUNTER, JKM SANDERS
– Proceedings of the Royal Society B: Biological Sciences
(1997)
248,
141
Synthesis and kinetic cyclisation of quinine-derived oligomers
SJ Rowan, PA Brady, JKM Sanders
– Tetrahedron Letters
(1996)
37,
6013
Can enzyme mimics compete with catalytic antibodies?
CJ Walter, LG Mackay, JKM Sanders
– CHEMICAL SYNTHESIS
(1996)
320,
419
Templated synthesis of enzyme mimics: How far can we go?
S Anderson, JKM Sanders
– CHEMICAL SYNTHESIS
(1996)
320,
277
Corrigenda
A VidalFerran, CM Muller, JKM Sanders
– Chem. Commun.
(1996)
1849
'Living' macrolactonisation: Thermodynamically-controlled cyclisation and interconversion of oligocholates
PA Brady, RP BonarLaw, SJ Rowan, CJ Suckling, JKM Sanders
– Chemical Communications
(1996)
319
Synthesis of cyclocholate-capped porphyrins
RP BonarLaw, JKM Sanders
– Journal of the Chemical Society Perkin Transactions 1
(1995)
3085
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Research Group

Research Interest Groups

Telephone number

01223 336411

Email address

jkms@cam.ac.uk