Research Associate
Education
2016 - PhD in Biophysical Chemistry, University of Cambridge
2011 - MSci in Natural Sciences, Chemistry, UNiversity of Cambridge
2010 - Cambridge-MIT Exchange Program, Massachusetts Institute of Technology
Research Interests
Development and application of fundamental biophysical theories to data analysis in a biologically relevant context, Protein Aggregation, Biophysical Chemistry, High Throughput Screening
Selected Publications
- G Meisl, E Hidari, K Allinson, T Rittman, SL DeVos, JS Sanchez, CK Xu, KE Duff, KA Johnson, JB Rowe, BT Hyman, TPJ Knowles and D Klenerman "In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease", Science Advances 7, eabh1448 (2021)
- G Meisl, T Kurt, I Condado-Morales, C Bett, S Sorce, M Nuvolone, TCT Michaels, D Heinzer, M Avar, SIA Cohen, S Horneman, A Aguzzi, CM Dobson, CJ Sigurdson and TPJ Knowles “Scaling analysis reveals the mechanism and rates of prion replication in vivo”, Nature Structural and Molecular Biology 28, 365 (2021)
- G Meisl, TPJ Knowles, D Klenerman “The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation.” Current Opinion in Neurobiology 61, 58 (2020)
- G Meisl, L Rajah, SAI Cohen, M Pfammatter, A Šarić, E Hellstrand, AK Buell, A Aguzzi, S Linse, M Vendruscolo, CM Dobson and TPJ Knowles, "Scaling behaviour and rate-determining steps in filamentous self-assembly", Chemcial Science (2017)
- G Meisl, X Yang, CM Dobson, S Linse and TPJ Knowles, "Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants", Chemical Science 8, 4352 (2017)
- G Meisl, JB Kirkegaard, P Arosio, M Vendruscolo, CM Dobson, S Linse and TPJ Knowles, “Molecular mechanisms of protein aggregation from global fitting of kinetic models”, Nature Protocols 11, 252 (2016)
- G Meisl, X Yang, E Hellstrand, B Frohm, JB Kirkegaard, SIA Cohen, CM Dobson, S Linse and TPJ Knowles, "Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides.", Proceedings of the National Academy of Sciences, 111, 9384 (2014)
Publications
A conformational switch controlling the toxicity of the prion protein
– Nature Structural & Molecular Biology
(2022)
29,
831
(doi: 10.1038/s41594-022-00814-7)
Both COVID-19 infection and vaccination induce high-affinity cross-clade responses to SARS-CoV-2 variants
– iScience
(2022)
25,
104766
(doi: 10.1016/j.isci.2022.104766)
Mechanistic Models of Protein Aggregation Across Length-Scales and Time-Scales: From the Test Tube to Neurodegenerative Disease
– Front Neurosci
(2022)
16,
909861
(doi: 10.3389/fnins.2022.909861)
Uncovering the universality of self-replication in protein aggregation and its link to disease
(2022)
(doi: 10.1101/2022.06.08.495339)
Microfluidic Antibody Affinity Profiling Reveals the Role of Memory Reactivation and Cross-Reactivity in the Defense Against SARS-CoV-2
– ACS Infectious Diseases
(2022)
8,
790
(doi: 10.1021/acsinfecdis.1c00486)
The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity
– Molecules
(2022)
27,
1293
(doi: 10.3390/molecules27041293)
The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity
– Molecules
(2022)
27,
1293
(doi: 10.3390/molecules27041293)
The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization.
– Communications Biology
(2022)
5,
123
(doi: 10.1038/s42003-022-03059-8)
Mechanism of secondary nucleation from the direct observation of Aβ42 aggregation at the single fibril level
– Biophysical Journal
(2022)
121,
443A
(doi: 10.1016/j.bpj.2021.11.556)
Rate‐limiting processes of tau aggregate accumulation in Alzheimer's disease
– Alzheimer's & Dementia
(2022)
17,
(doi: 10.1002/alz.051680)
- <
- 4 of 15