Research Associate
Education
2016 - PhD in Biophysical Chemistry, University of Cambridge
2011 - MSci in Natural Sciences, Chemistry, UNiversity of Cambridge
2010 - Cambridge-MIT Exchange Program, Massachusetts Institute of Technology
Research Interests
Development and application of fundamental biophysical theories to data analysis in a biologically relevant context, Protein Aggregation, Biophysical Chemistry, High Throughput Screening
Selected Publications
- G Meisl, E Hidari, K Allinson, T Rittman, SL DeVos, JS Sanchez, CK Xu, KE Duff, KA Johnson, JB Rowe, BT Hyman, TPJ Knowles and D Klenerman "In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease", Science Advances 7, eabh1448 (2021)
- G Meisl, T Kurt, I Condado-Morales, C Bett, S Sorce, M Nuvolone, TCT Michaels, D Heinzer, M Avar, SIA Cohen, S Horneman, A Aguzzi, CM Dobson, CJ Sigurdson and TPJ Knowles “Scaling analysis reveals the mechanism and rates of prion replication in vivo”, Nature Structural and Molecular Biology 28, 365 (2021)
- G Meisl, TPJ Knowles, D Klenerman “The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation.” Current Opinion in Neurobiology 61, 58 (2020)
- G Meisl, L Rajah, SAI Cohen, M Pfammatter, A Šarić, E Hellstrand, AK Buell, A Aguzzi, S Linse, M Vendruscolo, CM Dobson and TPJ Knowles, "Scaling behaviour and rate-determining steps in filamentous self-assembly", Chemcial Science (2017)
- G Meisl, X Yang, CM Dobson, S Linse and TPJ Knowles, "Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants", Chemical Science 8, 4352 (2017)
- G Meisl, JB Kirkegaard, P Arosio, M Vendruscolo, CM Dobson, S Linse and TPJ Knowles, “Molecular mechanisms of protein aggregation from global fitting of kinetic models”, Nature Protocols 11, 252 (2016)
- G Meisl, X Yang, E Hellstrand, B Frohm, JB Kirkegaard, SIA Cohen, CM Dobson, S Linse and TPJ Knowles, "Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides.", Proceedings of the National Academy of Sciences, 111, 9384 (2014)
Publications
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity (vol 114, pg E1009, 2017)
Proceedings of the National Academy of Sciences
(2017)
114
E2543
(doi: 10.1073/pnas.1701964114)
Acceleration of α-synuclein aggregation
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis
(2017)
24
20
A natural product inhibits the initiation of α-synuclein aggregation & suppresses its toxicity
Proc Natl Acad Sci U S A
(2017)
114
E1009
(doi: 10.1073/pnas.1610586114)
Attenuating the Toxicity of Amyloid-Beta Aggregation with Specific Species
Biophysical Journal
(2017)
112
494A
(doi: 10.1016/j.bpj.2016.11.2673)
Secondary nucleation of monomers on fibril surface dominates $\alpha$-synuclein aggregation and provides autocatalytic amyloid amplification
Q Rev Biophys
(2017)
50
e6
(doi: 10.1017/s0033583516000172)
β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces.
Scientific reports
(2016)
6
36010
(doi: 10.1038/srep36010)
Physical determinants of the self-replication of protein fibrils.
Nat Phys
(2016)
12
874
(doi: 10.1038/NPHYS3828)
Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation.
Proceedings of the National Academy of Sciences of the United States of America
(2016)
113
10328
(doi: 10.1073/pnas.1604645113)
Self-assembly of MPG1, a hydrophobin protein from the rice blast fungus that forms functional amyloid coatings, occurs by a surface-driven mechanism.
Scientific reports
(2016)
6
25288
(doi: 10.1038/srep25288)
Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones
Scientific reports
(2016)
6
24656
(doi: 10.1038/srep24656)
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