Yusuf Hamied Department of Chemistry

Emre Fertan

Research Associate

Publications

Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage-Specific Vulnerabilities in Alzheimer’s Disease
D Böken, PB Lobo, Y Wu, LA Rowe, E Fertan, CL Croft, M Jimenez-Sanchez, D Cox, D Klenerman
Advanced Science
(2026)
(doi: 10.1002/advs.77822)
Tau aggregate replication occurs at the pre-synapse of cultured human neurons and increases with application of TNFɑ
S Kedia, E Fertan, A Paul, V Davi, G Nolan, K Baranes, Y Wu, JE Kim, A Quaegebeur, MRN Kotter, E Avezov, G Meisl, D Klenerman
(2026)
(doi: 10.64898/2026.05.30.728997)
Single-molecule detection methods and super-resolution imaging to study alpha-synuclein aggregation in post-mortem Parkinson’s disease brains
D Klenerman
Cell reports methods
(2026)
6
(doi: 10.1016/j.crmeth.2026.101418)
Nanoscopic tau aggregates are not shared intermediates but disease-specific entities across tauopathies
D Böken, M Huang, Y Wu, E Fertan, MW Cotton, G Meisl, JYL Lam, S Baig, JB Rowe, C Smith, A Quaegebeur, D Cox, WA McEwan, D Klenerman
Cell reports
(2026)
45
(doi: 10.1016/j.celrep.2026.116934)
Neurodegeneration emerges at a cellular tipping point between aggregate accumulation and removal
MW Cotton, S Venkatesan, JS Beckwith, D Böken, CK Xu, E Fertan, JC Breiter, LE Berkowicz, LS Salazar, A Von Schulze, EA Andrzejewska, EE Brock, HL Han, MM Schneider, DD Sahtoe, D Baker, JB Rowe, A Goriely, WA McEwan, TPJ Knowles, SF Lee, R Halfmann, D Klenerman, G Meisl
(2025)
(doi: 10.1101/2025.09.08.674880)
Early synaptic pathology is associated with small tau aggregates in Alzheimer’s disease
E Fertan, S Kedia, G Meisl, MW Cotton, A Quaegebeur, MG Spillantini, D Klenerman
(2025)
(doi: 10.1101/2025.09.13.676039)
Super-resolution microscopy of nanoscopic alpha-synuclein aggregates in brain samples indicates a subset of cells have disrupted protein homeostasis prior to Lewy body formation in Parkinson’s disease
E Fertan, JSH Danial, S Neame, JYL Lam, MW Cotton, M Burke, Z Xia, Y Wu, B Powney, Y Imaizumi, A Quaegebeur, G Meisl, J Staddon, D Klenerman
(2025)
(doi: 10.1101/2025.09.16.676632)
Small-diffusible aggregates, plaques, tangles, and dynamic equilibria: Untangling Alzheimer's disease
E Fertan, G Meisl, D Klenerman
Alzheimer's & dementia : the journal of the Alzheimer's Association
(2025)
21
(doi: 10.1002/alz.70462)
Small tau aggregates exhibit disease-specific molecular profiles across tauopathies
D Böken, M Huang, Y Wu, E Fertan, JYL Lam, G Meisl, S Baig, JB Rowe, C Smith, A Quaegebeur, D Cox, WA McEwan, D Klenerman
(2025)
(doi: 10.1101/2025.06.10.658934)
Lysosomal stress induces amyloid-β aggregate release and reactive transformation in human astrocytes
S Goldsworthy, E Fertan, P Dyal, S Domoney, FJ Livesey, D Klenerman, R Patani, C Hung
(2025)
(doi: 10.1101/2025.05.27.656416)
Yusuf Hamied Department of Chemistry
Lensfield Road
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CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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