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Yusuf Hamied Department of Chemistry

 

Professor David Spring

Professor of Chemistry & Chemical Biology / EPSRC Established Career Research Fellow

 

Our research interests originate from a desire to understand and exploit biological systems using organic synthesis primarily. Listed below are areas of research that we are exploring; for more detailed information visit the Spring Group web pages.

We collaborate with many chemical companies and academic groups around the world. The scientific education of group members in organic synthesis is given a high priority; however, they are encouraged also to learn and perform new techniques relating to their projects with our industrial and academic collaborators. Every effort is made so that group members achieve their career ambitions, usually jobs in academia or the chemical industries.

Spring Group Figure

 

 

Watch Professor David Spring discuss his research

Take a quick tour of the Spring Lab

For more detailed information please visit the Spring Group research pages.

Teaching

If you are looking for the teaching material from my lecture courses, then please go to the Moodle website.

Publications

For a list of all our publications please visit the Spring Group publication page.

Publications

Development of small cyclic peptides targeting the CK2α/β interface.
EL Atkinson, J Iegre, C D'Amore, P Brear, M Salvi, M Hyvönen, DR Spring
– Chemical Communications
(2022)
58,
4791
(doi: 10.1039/d2cc00707j)
Divinylpyrimidine reagents generate antibody-drug conjugates with excellent in vivo efficacy and tolerability.
SJ Walsh, S Omarjee, FM Dannheim, D-L Couturier, D Bexheti, L Mendil, G Cronshaw, T Fewster, C Gregg, C Brodie, JL Miller, R Houghton, JS Carroll, DR Spring
– Chemical communications (Cambridge, England)
(2022)
58,
1962
(doi: 10.1039/d1cc06766d)
Energetics of lipid transport by the ABC transporter MsbA is lipid dependent
D Guo, H Singh, A Shimoyama, C Guffick, Y Tang, SM Rowe, T Noel, DR Spring, K Fukase, HW van Veen
– Commun Biol
(2021)
4,
1379
(doi: 10.1038/s42003-021-02902-8)
Targeting a Novel KRAS Binding Site: Application of One-Component Stapling of Small (5-6-mer) Peptides
G Fumagalli, RJ Carbajo, JWM Nissink, J Tart, R Dou, AP Thomas, DR Spring
– J Med Chem
(2021)
64,
17287
(doi: 10.1021/acs.jmedchem.1c01334)
Microscopy and chemical analyses reveal flavone-based woolly fibres extrude from micron-sized holes in glandular trichomes of Dionysia tapetodes
M Bourdon, J Gaynord, KH Müller, G Evans, S Wallis, P Aston, DR Spring, R Wightman
– BMC Plant Biology
(2021)
21,
258
(doi: 10.1186/s12870-021-03010-9)
Rapid and robust cysteine bioconjugation with vinylheteroarenes.
H Seki, SJ Walsh, JD Bargh, JS Parker, J Carroll, DR Spring
– Chem Sci
(2021)
12,
9060
(doi: 10.1039/d1sc02722k)
Historical Demographic Processes Dominate Genetic Variation in Ancient Atlantic Cod Mitogenomes
L Martínez-García, G Ferrari, T Oosting, R Ballantyne, I van der Jagt, I Ystgaard, J Harland, R Nicholson, S Hamilton-Dyer, HT Baalsrud, MSO Brieuc, LM Atmore, F Burns, U Schmölcke, KS Jakobsen, S Jentoft, D Orton, AK Hufthammer, JH Barrett, B Star
– Frontiers in Ecology and Evolution
(2021)
9,
671281
(doi: 10.3389/fevo.2021.671281)
The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions
BH Gan, J Gaynord, SM Rowe, T Deingruber, DR Spring
– Chemical Society Reviews
(2021)
50,
7820
(doi: 10.1039/d0cs00729c)
Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study.
EL Atkinson, J Iegre, PD Brear, EA Zhabina, M Hyvönen, DR Spring
– Molecules (Basel, Switzerland)
(2021)
26,
1977
(doi: 10.3390/molecules26071977)
A dual-enzyme cleavable linker for antibody-drug conjugates
JD Bargh, SJ Walsh, N Ashman, A Isidro-Llobet, JS Carroll, DR Spring
– Chemical communications (Cambridge, England)
(2021)
57,
3457
(doi: 10.1039/d1cc00957e)
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Research Group

Research Interest Groups

Telephone number

01223 336498

Email address

spring@ch.cam.ac.uk

College

Trinity College

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    About the University

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