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Yusuf Hamied Department of Chemistry

 

Our major research programme concerns the folding, stability and activity of proteins. We apply a broad multi-disciplinary approach that combines methods and ideas of molecular biology and physical-organic chemistry. We use techniques including protein engineering, DNA cloning, sequencing and mutagenesis, cell culture, gene and peptide synthesis, spectroscopy, rapid reaction techniques, multi-dimensional NMR (we have a 500, 600, 700 and an 800 MHz spectrometers) and x-ray protein crystallography.

Current major projects include: protein folding, misfolding and disease; drug discovery; and structure-activity relationships of proteins involved in cancer and disease.

Although now emeritus, I am still fully active in research with long term funding, including an MRC Programme Grant.

Publications

From Minichaperone to GroEL 1: Information on GroEL-polypeptide interactions from crystal packing of minichaperones
Q Wang, AM Buckle, AR Fersht
– Journal of Molecular Biology
(2000)
304,
873
From minichaperone to GroEL 2: Importance of avidity of the multisite ring structure
J Chatellier, F Hill, AR Fersht
– Journal of Molecular Biology
(2000)
304,
883
A kinetically significant intermediate in the folding of barnase.
AR Fersht
– Proc Natl Acad Sci U S A
(2000)
97,
14121
Protein folding and unfolding in microseconds to nanoseconds by experiment and simulation.
U Mayor, CM Johnson, V Daggett, AR Fersht
– Proceedings of the National Academy of Sciences
(2000)
97,
13518
Biophysical characterization of elongin C from Saccharomyces cerevisiae (vol 39, pg 11137, 2000)
A Buchberger, MJ Howard, SMV Freund, M Proctor, PJG Butler, AR Fersht, M Bycroft
– BIOCHEMISTRY
(2000)
39,
12512
The deleterious effect of polyglutamine aggregation in cell models of Huntington's disease.
DC Rubinsztein, J Carmichael, J Rankin, J Chatellier, A Woolfson, A Wyttenbach, C Milstein, AR Fersht
– AM J HUM GENET
(2000)
67,
410
Elucidating the mechanism of familial amyloidosis– Finnish type: NMR studies of human gelsolin domain 2
SL Kazmirski, MJ Howard, RL Isaacson, AR Fersht
– Proceedings of the National Academy of Sciences of the United States of America
(2000)
97,
10706
Biophysical Characterization of Elongin C from Saccharomyces cerevisiae
A Buchberger, MJ Howard, SM Freund, M Proctor, PJ Butler, AR Fersht, M Bycroft
– Biochemistry
(2000)
39,
12512
Conversion of two-state to multi-state folding kinetics on fusion of two protein foldons.
K Inaba, N Kobayashi, AR Fersht
– J Mol Biol
(2000)
302,
219
Biophysical characterization of elongin C from Saccharomyces cerevisiae
A Buchberger, MJ Howard, SM Freund, M Proctor, PJ Butler, AR Fersht, M Bycroft
– Biochemistry
(2000)
39,
11137
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