Yusuf Hamied Department of Chemistry

Alexander Roentgen

Research Associate

Publications

Low-abundance αSyn-112 promotes αSyn-140 aggregation in vitro and forms immunoreactive deposits in Parkinson’s disease brain tissue
A Röntgen, G Fusco, J Breiter, JS Beckwith, J Lachica, CE Toomey, J Singh, O Klementieva, S Gandhi, S Lee, AD Simone, Z Toprakcioglu, M Vendruscolo
(2026)
(doi: 10.64898/2026.07.05.736591)
Rational Design of Nanobodies Targeting LINGO‐1
A Röntgen, VR Chowdhury, A Ramon, M Greenig, X Xu, P Sormanni, M Vendruscolo
Applied Research
(2026)
5
(doi: 10.1002/appl.70071)
Effects of Alternative Splicing on α-Synuclein Phase Behaviour
A Roentgen
(2025)
(doi: 10.17863/CAM.132118)
Aβ42 promotes the aggregation of α-synuclein splice isoforms via heterogeneous nucleation
A Röntgen, Z Toprakcioglu, M Vendruscolo
FEBS letters
(2025)
599
(doi: 10.1002/1873-3468.70118)
Aggregation of α-synuclein splice isoforms through a phase separation pathway
A Roentgen, Z Toprakcioglu, ST Dada, OM Morris, TPJ Knowles, M Vendruscolo
Science Advances
(2025)
11
(doi: 10.1126/sciadv.adq5396)
The Preface
A Röntgen
BioFactors
(2024)
51
(doi: 10.1002/biof.2127)
The diversity of SNCA transcripts in neurons, and its impact on antisense oligonucleotide therapeutics
JR Evans, EK Gustavsson, I Doykov, D Murphy, GS Virdi, J Lachica, A Röntgen, MH Murtada, CW Pang, H Macpherson, AI Wernick, CE Toomey, D Athauda, ML Choi, J Hardy, NW Wood, M Vendruscolo, K Mills, W Heywood, M Ryten, S Gandhi
(2024)
(doi: 10.1101/2024.05.30.596437)
Pharmacological inhibition of α-synuclein aggregation within liquid condensates
ST Dada, Z Toprakcioglu, MP Cali, A Röntgen, MC Hardenberg, OM Morris, LK Mrugalla, TPJ Knowles, M Vendruscolo
Nature communications
(2024)
15
(doi: 10.1038/s41467-024-47585-x)
Modulation of α-synuclein in vitro aggregation kinetics by its alternative splice isoforms.
A Röntgen, Z Toprakcioglu, JE Tomkins, M Vendruscolo
Proceedings of the National Academy of Sciences of the United States of America
(2024)
121
(doi: 10.1073/pnas.2313465121)
Cell culture v1
A Röntgen
(2023)
(doi: 10.17504/protocols.io.36wgq3bk5lk5/v1)

Research Group

Telephone number

01223 748845, 01223 763845 (shared)

Email address

ahwr2@cam.ac.uk

College

Clare Hall
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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