Materials Chemistry Group and Pfizer Institute for Pharmaceutical Materials Science
Functional (pharmaceutical) molecular solids
The design of functional molecular materials has advanced tremendously through cocrystallisation: the assembly of multiple chemical species in the same crystal lattice. Underlying cocrystals formation are rules that guide molecular recognition and self-assembly. We are deciphering this "intermolecular language" by combining experimental work with data mining and molecular modelling. Our particular interest is constructing functional materials through weak supramolecular interactions, such as hydrogen and halogen bonds.
Surface dynamics of molecular solids
Properties of crystalline solids are usually measured as a bulk property, and the results interpreted in terms of crystal structure. However, such a description does not adequately describe the surface of molecular crystals, at which the distribution of forces on a molecule is non-symmetrical, resulting in high mobility and reactivity. The atomic force microscope (AFM) is a unique tool for studying such surface-related dynamics.
Mechanosynthesis: environmentally-friendly synthesis through grinding
The use of mechanical force, instead of heat, to transfer energy provides a rapid and clean way to conduct chemical reactions. We are especially interested in grinding as a means of conducting (almost!) solvent-free synthesis of materials that have catalytic or pharmaceutical significance, from the simplest and cheapest possible precursors (e.g. minerals).
Selected Publications
Crystal Growth and Design, (2009), 9, 1621;
CrystEngComm, (2009), 11, 470;
Chemistry - European Journal, (2008), 14, 8830;
Chemistry of Materials, (2008), 20, 6623;
Crystal Growth and Design, (2008), 8, 1605