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Yusuf Hamied Department of Chemistry

 

Professor of Chemistry

What we do...

We are designing hollow supramolecular capsules or ‘cages’, which can be used to transport cargoes of molecules where we need them. These cages could be used to safely deliver drug therapies, reduce the costs and environmental effects of petroleum refining, and in many other areas. 

Figuring out the rules

We are interested in discovering and developing new ways in which simple building blocks may be induced to self-assemble into complex, functional structures. Our investigations currently focus upon the self-assembly of imine bonds around metal-ion templates, bringing both covalent C=N and coordinative N→Metal bonds into being during the same overall self-assembly process. The structures thus created can rearrange in well-defined ways at both covalent and coordinative linkages. Ongoing projects include:

 

Container Molecules. The diamine and aldehyde shown above self-assemble with iron(II) in water to form a tetrahedral cage. This cage traps guest molecules within its cavity with high selectivity. The cage may be opened and the guest released using different triggers, one of which is a drop in pH. Applications in drug delivery are of interest, as are investigations of changes in the reactivity and behaviour of guest molecules upon encapsulation.

 

Functional Materials. We have recently developed means to create metal-containing conjugated polymers through self-assembly. DFT calculations carried out by Laura Gagliardi and Christopher Cramer suggest that these might conduct electricity. Studies are thus being undertaken to investigate their properties.

Watch Professor Nitschke discuss his research

Take a tour of the Nitschke Lab

 

Selected Publications

Feature Article: “Metal-organic container molecules through subcomponent self-assembly”, T.K. Ronson, S. Zarra, S.P. Black, J.R. Nitschke, Chem. Commun. 2013, 49, 2476-2490.

“Enantiopure Water-Soluble Fe4L6 Cages: Host-Guest Chemistry and Catalytic Activity”, Jeanne L. Bolliger, Ana M. Belenguer, and Jonathan R. Nitschke, Angew. Chem. Int. Ed. 2013, 52, 7958-7962.

“Aqueous Self-assembly of an Electroluminescent Double-helical Metallo-polymer”, X. de Hatten,  D. Asil, R.H. Friend, J.R. Nitschke,  J. Am. Chem. Soc. 2012, 135, 19170-19178.

“Anion-induced Reconstitution of a Self-assembling System to Express a Chloride-binding Co10L15 Pentagonal Prism”, I.A. Riddell, M.M.J. Smulders, J.K. Clegg, Y.R. Hristova, B. Breiner, J.D. Thoburn, J.R. Nitschke, Nature Chem. 2012, 51, 751-756.

 “White phosphorus is air-stable within a self-assembled tetrahedral capsule” P. Mal, B. Breiner, K. Rissanen and J.R. Nitschke, Science 2009, 324, 1697-1699.

“Systems chemistry: Molecular networks come of age” J.R. Nitschke, Nature 2009, 462, 736-738.

Publications

Publisher Correction: Allosteric regulation in metal–organic cages
Y Yang, Y Du, AW Heard, JR Nitschke
– Nature Synthesis
(2025)
Fluoride Enhances Alcohol Binding Within a Trigonal‐Prismatic Metal‐Organic Capsule
Y Yang, TK Ronson, D Hou, KH Luo, JR Nitschke
– Angewandte Chemie
(2025)
e202505137
Fluoride Enhances Alcohol Binding Within a Trigonal-Prismatic Metal-Organic Capsule
Y Yang, TK Ronson, D Hou, KH Luo, JR Nitschke
– Angewandte Chemie (International ed. in English)
(2025)
e202505137
Allosteric regulation in metal–organic cages
Y Yang, Y Du, AW Heard, JR Nitschke
– Nature Synthesis
(2025)
4,
537
Proton-driven lithium separation using alkali-templated coordination cages
X Sun, K Wu, PCP Teeuwen, P Pracht, DJ Wales, JR Nitschke
– Chem
(2025)
102556
Development of an Automated Workflow for Screening the Assembly and Host–Guest Behavior of Metal‐Organic Cages Towards Accelerated Discovery
AR Basford, AH Bernardino, PCP Teeuwen, BD Egleston, J Humphreys, KE Jelfs, JR Nitschke, IA Riddell, RL Greenaway
– Angewandte Chemie
(2025)
e202424270
Development of an Automated Workflow for Screening the Assembly and Host–Guest Behavior of Metal-Organic Cages Towards Accelerated Discovery
AR Basford, AH Bernardino, PCP Teeuwen, BD Egleston, J Humphreys, KE Jelfs, JR Nitschke, IA Riddell, RL Greenaway
– Angewandte Chemie (International ed. in English)
(2025)
e202424270
Fluoride Enhances Alcohol Binding within a Trigonal-Prismatic Metal-Organic Capsule
Y Yang, TK Ronson, D Hou, KH Luo, JR Nitschke
(2025)
Higher-Order CuI‑Based Cages via Subcomponent Self-Assembly
H Zhu, NMA Speakman, TK Ronson, JR Nitschke
– Accounts of Chemical Research
(2025)
58,
1296
Two (AgI 3I)4L4 cages elucidate the rules for silver-cluster vertex design
AW Heard, SE Clark, CT McTernan, TK Ronson, P Rozhin, B Rossi, S Marchesan, JR Nitschke
– Chem
(2025)
102456
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Research Group

Research Interest Groups

Telephone number

01223 336324

Email address

jrn34@cam.ac.uk