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Professor Bill Jones

Portrait of wj10

Materials Chemistry Group

Functional (pharmaceutical) molecular solids

The design of functional molecular materials has advanced tremendously through cocrystallisation: the assembly of multiple chemical species in the same crystal lattice. Underlying cocrystals formation are rules that guide molecular recognition and self-assembly. We are deciphering this "intermolecular language" by combining experimental work with data mining and molecular modelling. Our particular interest is constructing functional materials through weak supramolecular interactions, such as hydrogen and halogen bonds.

Surface dynamics of molecular solids

Properties of crystalline solids are usually measured as a bulk property, and the results interpreted in terms of crystal structure. However, such a description does not adequately describe the surface of molecular crystals, at which the distribution of forces on a molecule is non-symmetrical, resulting in high mobility and reactivity. The atomic force microscope (AFM) is a unique tool for studying such surface-related dynamics.

 

Teaching

 

Current teaching includes a third year undergraduate lecture course on the Chemistry of Materials.  The course examines a range of organic, metal-organic and inorganic materials and demonstrates their varied uses. We will, in particular, identify important structural features relevant to such areas as the pharmaceutical and petrochemical industries and to naturally occurring biomaterials such as bone. The underlying chemistry and properties will be shown to be often sensitive to the way that the constituent atoms and molecules are packed together. This aspect of solid state control will be examined in some detail.

The development and design of new materials, incorporating structural characteristics of inorganic solids and functionality of organic molecules will be described.

The control of crystal morphology is important in many applications, and this will be discussed in the context of templating crystal growth, both in Nature and in the laboratory, and of crystal engineering. Numerous important materials, including many found in Nature, are in fact inorganic-organic composites, and these will also be discussed in detail.

From paracetamol to petrol to proteins to bone – the importance of the Chemistry of Materials will be explored in these lectures.

Also, as part of the Cambridge fourth year program I teach a course on Organic Solids that builds on the lecture course Chemistry of Materials given in Part II (although it is not required that students have taken this course). The first six lectures of the course, given by me, will cover aspects of crystal chemistry, structure and reactivity of organic solids. Examples of lattice controlled reactions will be given, including photochemical and thermal. Particular emphasis will be placed on how solid state properties impact on the development of drug products in the pharmaceutical industry. Experimental approaches to understanding molecular packing will be described and will lead into the second part of the course, given by my colleague, Dr Graeme Day.

Publications

Cocrystal dissociation in the presence of water: A general approach for identifying stable cocrystal forms
MD Eddleston, N Madusanka, W Jones – Journal of pharmaceutical sciences (2014) 103, 2865
Polymorphs, hydrates and solvates of a co-crystal of caffeine with anthranilic acid.
N Madusanka, MD Eddleston, M Arhangelskis, W Jones – Acta Crystallogr B Struct Sci Cryst Eng Mater (2014) 70, 72
An investigation of the causes of cocrystal dissociation at high humidity
MD Eddleston, R Thakuria, BJ Aldous, W Jones – Journal of pharmaceutical sciences (2014) 103, 2859
Use of in situ atomic force microscopy to follow phase changes at crystal surfaces in real time.
R Thakuria, MD Eddleston, EH Chow, GO Lloyd, BJ Aldous, JF Krzyzaniak, AD Bond, W Jones – Angew Chem Int Ed Engl (2013) 52, 10541
Ultrasound-assisted construction of halogen-bonded nanosized cocrystals that exhibit thermosensitive luminescence
D Yan, DK Bučar, A Delori, B Patel, GO Lloyd, W Jones, X Duan – Chemistry (2013) 19, 8213
Determination of the crystal structure of a new polymorph of theophylline
MD Eddleston, KE Hejczyk, EG Bithell, GM Day, W Jones – Chemistry (2013) 19, 7883
Polymorph identification and crystal structure determination by a combined crystal structure prediction and transmission electron microscopy approach
MD Eddleston, KE Hejczyk, EG Bithell, GM Day, W Jones – Chemistry (2013) 19, 7874
Advantages of mechanochemical cocrystallisation in the solid-state chemistry of pigments: colour-tuned fluorescein cocrystals
D-K Bučar, S Filip, M Arhangelskis, GO Lloyd, W Jones – CrystEngComm (2013) 15, 6289
Cocrystallization by Freeze-Drying: Preparation of Novel Multicomponent Crystal Forms
MD Eddleston, B Patel, GM Day, W Jones – Crystal Growth & Design (2013) 13, 4599
Cocrystals of 5-fluorouracil
A Delori, MD Eddleston, W Jones – CrystEngComm (2013) 15, 73
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Research Interest Group

Telephone number

01223 336468

Email address

wj10@cam.ac.uk