skip to content
 

Professor Bill Jones

Portrait of wj10

Materials Chemistry Group

Functional (pharmaceutical) molecular solids

The design of functional molecular materials has advanced tremendously through cocrystallisation: the assembly of multiple chemical species in the same crystal lattice. Underlying cocrystals formation are rules that guide molecular recognition and self-assembly. We are deciphering this "intermolecular language" by combining experimental work with data mining and molecular modelling. Our particular interest is constructing functional materials through weak supramolecular interactions, such as hydrogen and halogen bonds.

Surface dynamics of molecular solids

Properties of crystalline solids are usually measured as a bulk property, and the results interpreted in terms of crystal structure. However, such a description does not adequately describe the surface of molecular crystals, at which the distribution of forces on a molecule is non-symmetrical, resulting in high mobility and reactivity. The atomic force microscope (AFM) is a unique tool for studying such surface-related dynamics.

 

Teaching

 

Current teaching includes a third year undergraduate lecture course on the Chemistry of Materials.  The course examines a range of organic, metal-organic and inorganic materials and demonstrates their varied uses. We will, in particular, identify important structural features relevant to such areas as the pharmaceutical and petrochemical industries and to naturally occurring biomaterials such as bone. The underlying chemistry and properties will be shown to be often sensitive to the way that the constituent atoms and molecules are packed together. This aspect of solid state control will be examined in some detail.

The development and design of new materials, incorporating structural characteristics of inorganic solids and functionality of organic molecules will be described.

The control of crystal morphology is important in many applications, and this will be discussed in the context of templating crystal growth, both in Nature and in the laboratory, and of crystal engineering. Numerous important materials, including many found in Nature, are in fact inorganic-organic composites, and these will also be discussed in detail.

From paracetamol to petrol to proteins to bone – the importance of the Chemistry of Materials will be explored in these lectures.

Also, as part of the Cambridge fourth year program I teach a course on Organic Solids that builds on the lecture course Chemistry of Materials given in Part II (although it is not required that students have taken this course). The first six lectures of the course, given by me, will cover aspects of crystal chemistry, structure and reactivity of organic solids. Examples of lattice controlled reactions will be given, including photochemical and thermal. Particular emphasis will be placed on how solid state properties impact on the development of drug products in the pharmaceutical industry. Experimental approaches to understanding molecular packing will be described and will lead into the second part of the course, given by my colleague, Dr Graeme Day.

Publications

Rationalization of the Color Properties of Fluorescein in the Solid State: A Combined Computational and Experimental Study
M Arhangelskis, MD Eddleston, DG Reid, GM Day, D-K Bučar, AJ Morris, W Jones
– Chemistry
(2016)
22,
10065
Polymer-Assisted Grinding, a Versatile Method for Polymorph Control of Cocrystallization
D Hasa, E Carlino, W Jones
– Crystal Growth & Design
(2016)
16,
1772
Investigation of an Amide-Pseudo Amide Hydrogen Bonding Motif within a Series of Theophylline:Amide Cocrystals
MD Eddleston, M Arhangelskis, L Fabian, GJ Tizzard, SJ Coles, W Jones
– Crystal Growth & Design
(2016)
16,
51
Comparison of surface techniques for the discrimination of polymorphs
R Thakuria, MD Eddleston, EHH Chow, LJ Taylor, BJ Aldous, JF Krzyzaniak, W Jones
– CrystEngComm
(2016)
18,
5296
Highly Unusual Triangular Crystals of Theophylline: The Influence of Solvent on the Growth Rates of Polar Crystal Faces
MD Eddleston, KE Hejczyk, AMC Cassidy, HPG Thompson, GM Day, W Jones
– Crystal Growth & Design
(2015)
15,
2514
Highlights from Faraday Discussion 170: challenges and opportunities of modern mechanochemistry, Montreal, Canada, 2014.
T Friščić, SL James, EV Boldyreva, C Bolm, W Jones, J Mack, JW Steed, KS Suslick
– Chemical communications (Cambridge, England)
(2015)
51,
6248
Cocrystal Formation through Mechanochemistry: from Neat and Liquid-Assisted Grinding to Polymer-Assisted Grinding.
D Hasa, GS Rauber, D Voinovich, W Jones
– Angew Chem Int Ed Engl
(2015)
54,
7371
Crystalline adducts of the Lawsone molecule(2-hydroxy-1,4-naphthaquinone): optical properties and computational modelling
A Pallipurath, JM Skelton, A Delori, C Duffy, A Erxleben, W Jones
– CrystEngComm
(2015)
17,
7684
Probing solid-state reaction mechanisms with THz-TDS
EPJ Parrott, JA Zeitler, T Friscic, W Jones, LF Gladden
– International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz
(2014)
Sonocrystallization Yields Monoclinic Paracetamol with Significantly Improved Compaction Behavior
D-K Bučar, JA Elliott, MD Eddleston, JK Cockcroft, W Jones
– Angew Chem Int Ed Engl
(2015)
54,
249
  •  
  • 1 of 39
  • >

Research Interest Groups

Telephone number

01223 336468

Email address

wj10@cam.ac.uk