Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Autoradiographic localization of [22,23-H-3(2)] dihydroazadirachtin binding sites in desert locust testes and effects of Azadirachtin on sperm motility
Tissue & cell
(1996)
28
725
Dispiroketals in Synthesis (Part 22)1: Use of Chiral 2,2′-Bis(phenylthiomethyl)-dihydropyrans as New Protecting and Resolving Agents for 1,2-Diols
Synlett
(1996)
1996
791
(doi: 10.1055/s-1996-5522)
Dispiroketals: A new functional group for organic synthesis
Contemporary Organic Synthesis
(1995)
2
365
(doi: 10.1039/CO9950200365)
Spiroketal glycomimetics: the synthesis of a conformationally restrained Sialyl Lewis X mimic
Bioorganic and Medicinal Chemistry Letters
(1995)
5
2637
(doi: 10.1016/0960-894X(95)00469-A)
DISPIROKETALS IN SYNTHESIS .18. REGIOSELECTIVE AND ENANTIOSELECTIVE PROTECTION OF SYMMETRICAL POLYOL SUBSTRATES USING AN ENANTIOPURE (2S,2'S)-DIMETHYL-BIS-DIHYDROPYRAN (SEPTEMBER, PG 898, 1995)
SYNLETT
(1995)
1196
Solid Phase Synthesis of Bicyclo[2.2.2]octane Derivatives via Tandem Michael Addition Reactions and Subsequent Reductive Amination
Synlett
(1995)
1995
1017
(doi: 10.1055/s-1995-5164)
DISPIROKETALS IN SYNTHESIS .19. DISPIROKETALS AS ENANTIOSELECTIVE AND REGIOSELECTIVE PROTECTIVE AGENTS FOR SYMMETRICAL CYCLIC AND ACYCLIC POLYOLS
Tetrahedron Asymmetry
(1995)
6
2403
(doi: 10.1016/0957-4166(95)00318-j)
Behavioural and neurophysiological responses of Spodoptera littoralis to azadirachtin and a range of synthetic analogues.
Entomologia experimentalis et applicata.
(1995)
77
69
Dispiroketals in synthesis (Part 18) 1 : Regioselective and enantioselective protection of symmetric polyol substrates using an enantiopure (2 S,2' S)-Dimethyl- bis -dihydropyran
Synlett
(1995)
1995
898
(doi: 10.1055/s-1995-5122)
SYNTHESIS AND CHEMISTRY OF THE INSECT ANTIFEEDANT AZADIRACHTIN
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(1995)
210
24
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