In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
Directed syntheses of the isomeric dimethylcyclooctatetraenes and a study of their polarographic and alkali metal reduction
LA PAQUETTE, SV LEY, MEISINGE.RH, RK RUSSELL, M OKU - Journal of the American Chemical Society (
1974)
96, 5806
(DOI:
10.1021/ja00825a019)
Aryne chemistry. Part XXXV. Reactions of arynes with 1-amino-cycloalkenes and hydrolyses of the adducts
H HEANEY, SV LEY - J CHEM SOC PERK T 1 (
1974), 2693
(DOI:
10.1039/p19740002693)
Aryne chemistry. Part XXXIV. Reactions of NN-dimethylarylamines with tetrahalogenobenzynes
JPN BREWER, H HEANEY, SV LEY, TJ WARD - J CHEM SOC PERK T 1 (
1974), 2688
(DOI:
10.1039/p19740002688)
ARYNE CHEMISTRY .33. REACTIONS OF TETRAHALOGENOBENZYNES WITH METHOXYARENES AND PHOTOLYSIS AND THERMOLYSIS OF SOME OF PRODUCTS
PC BUXTON, NJ HALES, B HANKINSON, H HEANEY, SV LEY, RP SHARMA - J CHEM SOC PERK T 1 (
1974), 2681
(DOI:
10.1039/p19740002681)
An efficient synthesis of (-)-triquinacene-2-carboxylic acid [42]
LA PAQUETTE, SV LEY, WB FARNHAM - Journal of the American Chemical Society (
1974)
96, 312
(DOI:
10.1021/ja00808a081)
ALKALI-METAL REDUCTION STUDIES OF CIS-BICYCLO AND TRANS-BICYCLO[610]NONA-2,4,6-TRIENES IN LIQUID-AMMONIA - EVIDENCE FOR HIGH BASICITY OF MONOHOMOCYCLOOCTATETRAENE DIANIONS
SV LEY, LA PAQUETTE - Journal of the American Chemical Society (
1974)
96, 6670
(DOI:
10.1021/ja00828a021)
Rearrangement reactions of bicyclic systems. Part I. Synthesis of a model compound related to flavothebaone trimethyl ether. The abnormal ultraviolet absorption spectrum of flavothebaone and its trimethyl ether
H HEANEY, HOLLINSH.JH, GW KIRBY, SV LEY, RP SHARMA, KW BENTLEY - J CHEM SOC PERK T 1 (
1973), 1840
(DOI:
10.1039/p19730001840)
N-Alkylation of indole and pyrroles in dimethyl sulphoxide
H HEANEY, SV LEY - J CHEM SOC PERK T 1 (
1973), 499
(DOI:
10.1039/p19730000499)
Mećhanistic dichotomy in cycloadditions to cyclooctatetraeneiron tricarbonyl. X-ray crystal structure analysis of the TCNE and CSI adducts
LA PAQUETTE, SV LEY, BROADHUR.MJ, TRUESDEL.D, J FAYOS, J CLARDY - Tetrahedron Letters (1973) 14, 2943
Thermal reactions of 1,4-bridged-1,2,3,4-tetrahydronaphthalene derivatives
H HEANEY, AP PRICE, RP SHARMA, SV LEY - Tetrahedron Letters (1972) 13, 3067
