In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
Oxidation of alcohols using benzeneseleninic anhydride
DHR BARTON, AG BREWSTER, AHF HUI, DJ LESTER, SV LEY, TG BACK - Journal of the Chemical Society, Chemical Communications (
1978), 952
(DOI:
10.1039/c39780000952)
Design of a specific oxidant for phenols.
D Barton, SV Ley - Ciba Foundation symposium (1978), 53
Dehydrogenation of steroidal ketones using benzeneseleninic anhydride
DHR BARTON, DJ LESTER, SV LEY - Journal of the Chemical Society, Chemical Communications (
1978), 130
(DOI:
10.1039/c39780000130)
Conversion of thiocarbonyl compounds into their corresponding oxo derivatives using benzeneseleninic anhydride
DHR BARTON, NJ CUSSANS, SV LEY - Journal of the Chemical Society, Chemical Communications (
1978), 393
(DOI:
10.1039/c39780000393)
X-Ray evidence for partial bonding between sulphur or selenium and oxygen in thio- and seleno-imines
A ATKINSON, AD BREWSTER, SV LEY, RS OSBORN, D ROGERS, DJ WILLIAMS, KA WOODE - Journal of the Chemical Society, Chemical Communications (
1977), 325
(DOI:
10.1039/c39770000325)
The question of delocalization in "anchored" ions with potential trishomoaromatic character. 1. Reduction of tricyclo[5.4.1.04,12]dodeca-2,5,8,10-tetraene as a route to the 10π11C dianion
LA PAQUETTE, MJ KUKLA, SV LEY, SG TRAYNOR - Journal of the American Chemical Society (
1977)
99, 4756
(DOI:
10.1021/ja00456a037)
REMOVAL OF 1,3-DITHIOLAN PROTECTING GROUPS BY BENZENESELENINIC ANHYDRIDE
DHR BARTON, NJ CUSSANS, SV LEY - Journal of the Chemical Society, Chemical Communications (
1977), 751
(DOI:
10.1039/c39770000751)
Regeneration of ketones from hydrazones, oximes, and semicarbazones by benzeneseleninic anhydride
DHR BARTON, DJ LESTER, SV LEY - Journal of the Chemical Society, Chemical Communications (
1977), 445
(DOI:
10.1039/c39770000445)
Reaction of tetracycline hydrochloride with N-chlorosuccinimide: X-ray crystal structure of the major product
DHR BARTON, SV LEY, K MEGURO, DJ WILLIAMS - Journal of the Chemical Society, Chemical Communications (
1977), 790
(DOI:
10.1039/c39770000790)
Preparation of phenylselenoimines from phenols using diphenylseleninic anhydride and hexamethyldisilazane
DHR BARTON, AG BREWSTER, SV LEY, MN ROSENFELD - Journal of the Chemical Society, Chemical Communications (
1977), 147
(DOI:
10.1039/c39770000147)
