In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
Oxidation of phenols to ortho-quinones using diphenylseleninic anhydride
DHR BARTON, AG BREWSTER, SV LEY, MN ROSENFELD - Journal of the Chemical Society, Chemical Communications (
1976), 985
(DOI:
10.1039/c39760000985)
HOMOTROPYLIUM-8-SULFINATE COMPLEXES BY SBF5-PROMOTED RING-OPENING OF 9-THIABICYCLO[4.2.1]NONA-2,4,7-TRIENE AND 9-THIABARBARALANE 9,9-DIOXIDES
LA PAQUETTE, U JACOBSSON, SV LEY - Journal of the American Chemical Society (
1976)
98, 152
(DOI:
10.1021/ja00417a023)
Formation of monohomocyclooctatetraene dianions in liquid ammonia. Analysis of the nucleophilic reactivity of the cyclononatrienyl anions generated upon solvent protonation
LA PAQUETTE, SV LEY, SG TRAYNOR, JT MARTIN, JM GECKLE - Journal of the American Chemical Society (
1976)
98, 8162
(DOI:
10.1021/ja00441a046)
The stability of NN-dialkylthiohydroxylamines
DHR BARTON, SV LEY, PD MAGNUS - Journal of the Chemical Society, Chemical Communications (
1975), 855
(DOI:
10.1039/c39750000855)
TETRACYANOETHYLENE ADDITION TO IRON TRICARBONYL COMPLEXES OF SUBSTITUTED CYCLOOCTATETRAENES - REGIOSELECTIVITY CONSIDERATIONS DURING FORMATION OF 2,3,4,10-TETRAHAPTO ADDUCTS
LA PAQUETTE, SV LEY, S MAIORANA, DF SCHNEIDER, MJ BROADHURST, RA BOGGS - Journal of the American Chemical Society (
1975)
97, 4658
(DOI:
10.1021/ja00849a031)
Synthesis, chiroptical properties, and absolute configuration of (+)-2,3-dihydrotriquinacen-2-one. effect of rigid triquinacene geometry on the inherently dissymmetric chromophore
LA PAQUETTE, WB FARNHAM, SV LEY - Journal of the American Chemical Society (
1975)
97, 7273
(DOI:
10.1021/ja00858a600)
NITROGEN ANALOGS OF 1,6-METHANO[12]ANNULENE - EFFECT ON VALENCE TAUTOMERISM OF LOCUS OF AZA SUBSTITUTION
LA PAQUETTE, HC BERK, SV LEY - Journal of Organic Chemistry (
1975)
40, 902
(DOI:
10.1021/jo00895a020)
Rearrangement reactions of bicyclic systems. Part IV. Acid-catalysed rearrangements of 5,6,7,8-tetrafluoro-1,4-dihydro-1-methoxy-3,9-dimethyl-1,4-ethenonaphthalene (1-methoxy-3,5-dimethyltetrafluorobenzobarrelene)
H HEANEY, SV LEY - J CHEM SOC PERK T 1 (
1974), 2711
(DOI:
10.1039/p19740002711)
Rearrangement reactions of bicyclic systems. Part III. Acid-catalysed rearrangements of 1,4-dihydro-1-methoxy-1,4-ethenonaphthalene (1-methoxyhenzobarrelene) and its 5,6,7,8-tetrahalogeno-derivatives
NJ HALES, H HEANEY, SV LEY - J CHEM SOC PERK T 1 (
1974), 2702
(DOI:
10.1039/p19740002702)
REARRANGEMENT REACTIONS OF BICYCLIC SYSTEMS .2. REARRANGEMENTS OF 1-DIMETHYLAMINO-5,6,7,8-TETRAHALOGENO-1,4-DIHYDRO-1,4-ETHENONAPHTHALENE DERIVATIVES AND ANALOGOUS 5,6,7,8-TETRAFLUORO-1,4-DIHYDRO-N-METHYL-1,4-IMINONAPHTHALENE IN AQUEOUS-SOLUTIONS
H HEANEY, SV LEY - J CHEM SOC PERK T 1 (
1974), 2698
(DOI:
10.1039/p19740002698)
