In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
Preparation of episulphides from alkenes via succinimide-N-sulphenyl chloride or phthalimide-N-sulphenyl chloride adducts
MU BOMBALA, SV LEY - J CHEM SOC PERK T 1 (
1979), 3013
(DOI:
10.1039/p19790003013)
Preparation of aldehydes and ketones by oxidation of benzylic hydrocarbons with benzeneseleninic anhydride
DHR BARTON, RAHF HUI, DJ LESTER, SV LEY - Tetrahedron Letters (
1979)
20, 3331
(DOI:
10.1016/S0040-4039(01)95401-2)
Isolation, Characterisation and Oxidation of Isomeric Ferrelactone Complexes.
GD ANNIS, SV LEY, R SIVARAMAKRISHNAN, AM ATKINSON, D ROGERS, DJ WILLIAMS - Journal of Organometallic Chemistry (
1979)
182, C11
(DOI:
10.1016/S0022-328X(00)85886-6)
Bis(p-methoxyphenyl) telluroxide: A new, mild oxidising agent
DHR BARTON, SV LEY, CA MEERHOLZ - Journal of the Chemical Society, Chemical Communications (
1979), 755
(DOI:
10.1039/c39790000755)
UNSATURATED HETEROCYCLIC-SYSTEMS .98. SYNTHESIS AND REDUCIBILITY OF HOMO-2-METHOXYAZOCINES AND THEIR BENZO-FUSED DERIVATIVES - EXAMINATION OF HETEROATOMIC INFLUENCES ON POSSIBLE GENERATION OF 9C-10-PI HOMOAROMATIC DIANIONS
LA PAQUETTE, GD EWING, SV LEY, HC BERK, SG TRAYNOR - J ORG CHEM (
1978)
43, 4712
(DOI:
10.1021/jo00419a007)
UNSATURATED HETEROCYCLIC-SYSTEMS .97. THERMAL-ISOMERIZATION OF HOMOAZOCINES
GD EWING, SV LEY, LA PAQUETTE - J AM CHEM SOC (
1978)
100, 2909
(DOI:
10.1021/ja00477a066)
Thermal isomerization of homoazocines [13]
GD Ewing, SV Ley, LA Paquette - Journal of the American Chemical Society (
1978)
100, 2909
(DOI:
10.1021/ja00477a066)
The formation of unusual sultones during the rearrangement reactions of bicyclic ketones
DS BROWN, H HEANEY, SV LEY, KG MASON, P SINGH - Tetrahedron Letters (
1978)
19, 3937
(DOI:
10.1016/S0040-4039(01)95103-2)
Synthesis and reducibility of homo-2-methoxyazocines and their benzo-fused derivatives. An examination of heteroatomic influences on the possible generation of 9C-10π homoaromatic dianions
LA Paquette, GD Ewing, SV Ley, HC Berk, SG Traynor - Journal of Organic Chemistry (
1978)
43, 4712
(DOI:
10.1021/jo00419a007)
Oxidation of aldehyde hydrazones, hydrazo compounds, and hydroxylamines with benzeneseleninic anhydride
DHR BARTON, DJ LESTER, SV LEY - Journal of the Chemical Society, Chemical Communications (
1978), 276
(DOI:
10.1039/c39780000276)
