In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
N-Alkylation of indole and pyrroles in dimethyl sulphoxide
H HEANEY, SV LEY - J CHEM SOC PERK T 1 (
1973), 499
(DOI:
10.1039/p19730000499)
Mećhanistic dichotomy in cycloadditions to cyclooctatetraeneiron tricarbonyl. X-ray crystal structure analysis of the TCNE and CSI adducts
LA PAQUETTE, SV LEY, BROADHUR.MJ, TRUESDEL.D, J FAYOS, J CLARDY - Tetrahedron Letters (1973) 14, 2943
Thermal reactions of 1,4-bridged-1,2,3,4-tetrahydronaphthalene derivatives
H HEANEY, AP PRICE, RP SHARMA, SV LEY - Tetrahedron Letters (
1972)
13, 3067
(DOI:
10.1016/S0040-4039(01)85010-3)
MULTIPLE REARRANGEMENT REACTIONS OF 1-METHOXYBENZOBARRELENE (1,4-DIHYDRO-1-METHOXY-1,4-ETHENONAPHTHALENE) DERIVATIVES
H HEANEY, SV LEY - Journal of the Chemical Society D: Chemical Communications (
1971), 224
(DOI:
10.1039/c29710000224)
ACID-CATALYSED REARRANGEMENTS OF 3,5-DIMETHYL-1-METHOXY-TETRAFLUORO-BENZOBARRELENE (5,6,7,8-TETRAFLUORO-1,4-DIHYDRO-3,10-DIMETHYL-1-METHOXY-1,4-ETHENONAPHTHALENE)
H HEANEY, SV LEY - Journal of the Chemical Society D: Chemical Communications (
1971), 1342
(DOI:
10.1039/c29710001342)
REARRANGEMENT REACTIONS OF 1-NN-DIMETHYLAMINOBENZOBARRELENE DERIVATIVES (BENZOBARRELENE =1,4-DIHYDRO-1,4-ETHENONAPHTHALENE)
H HEANEY, SV LEY - Journal of the Chemical Society D: Chemical Communications (
1970), 1184
(DOI:
10.1039/c29700001184)
