In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
Cyclisation reactions of alkenyl β-ketoesters involving a novel phenylseleno group migration
WP JACKSON, SV LEY, JA MORTON - Tetrahedron Letters (
1981)
22, 2601
(DOI:
10.1016/S0040-4039(01)90531-3)
AN INTRAMOLECULAR DIELS-ALDER APPROACH TO THE SYNTHESIS OF THE RIGHT HAND HALF OF THE IONOPHORE ANTIBIOTIC X-14547A
MP EDWARDS, SV LEY, SG LISTER - Tetrahedron Letters (
1981)
22, 361
(DOI:
10.1016/0040-4039(81)80099-8)
A convenient preparation of 2-haloenones from enones using phenylselenium halides
SV LEY, AJ WHITTLE - Tetrahedron Letters (
1981)
22, 3301
(DOI:
10.1016/S0040-4039(01)81890-6)
Thermal decomposition of tricarbonyliron lactone complexes
GD ANNIS, SV LEY, CR SELF, R SIVARAMAKRISHNAN - Journal of the Chemical Society, Chemical Communications (
1980), 299
(DOI:
10.1039/c39800000299)
SULFURATION OF ELECTRON-RICH ARENES WITH SULFENAMIDES AND AMINOSULFENYL CHLORIDES
MU BOMBALA, SV LEY - SYNTHETIC COMMUNICATIONS (
1980)
10, 291
(DOI:
10.1080/00397918008062752)
Selenium-mediated cyclization reactions of alkenyl-substituted β-ketoesters
WP JACKSON, SV LEY, AJ WHITTLE - Journal of the Chemical Society, Chemical Communications (
1980), 1173
(DOI:
10.1039/c39800001173)
Removal of thioacetal protecting groups by benzeneseleninic anhydride
NJ CUSSANS, SV LEY, DHR BARTON - J CHEM SOC PERK T 1 (
1980), 1654
(DOI:
10.1039/p19800001654)
Oxidation of ketone and aldehyde hydrazones, oximes, and semicarbazones and of hydroxylamines and hydrazo-compounds, using benzeneseleninic anhydride
DHR BARTON, DJ LESTER, SV LEY - J CHEM SOC PERK T 1 (
1980), 1212
(DOI:
10.1039/p19800001212)
Organosulphur, organoselenium, and organotellurium chemistry
SV Ley - Annual Reports Section "B" (Organic Chemistry) (1980) 77, 233
New cyclization procedure for alkenyl-substituted β-dicarbonyl compounds using N-phenylselenophthalimide
WP JACKSON, SV LEY, JA MORTON - Journal of the Chemical Society, Chemical Communications (
1980), 1028
(DOI:
10.1039/c39800001028)
