In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
Formation of β-lactams from tricarbonyliron lactone complexes
GD ANNIS, EM HEBBLETHWAITE, SV LEY - Journal of the Chemical Society, Chemical Communications (
1980), 297
(DOI:
10.1039/c39800000297)
Dehydrogenation of steroidal and triterpenoid ketones using benzeneseleninic anhydride
DHR BARTON, DJ LESTER, SV LEY - J CHEM SOC PERK T 1 (
1980), 2209
(DOI:
10.1039/p19800002209)
Conversion of thiocarbonyl compounds into their corresponding oxo-derivatives using benzeneseleninic anhydride
NJ CUSSANS, SV LEY, DHR BARTON - J CHEM SOC PERK T 1 (
1980), 1650
(DOI:
10.1039/p19800001650)
CATALYTIC-OXIDATION OF THIOCARBONYL COMPOUNDS INVOLVING THE USE OF 1,2-DIBROMOTETRACHLOROETHANE AS A BROMINATING REAGENT FOR DIARYL TEII SPECIES
SV LEY, CA MEERHOLZ, DHR BARTON - Tetrahedron Letters (
1980)
21, 1785
(DOI:
10.1016/S0040-4039(00)77838-5)
A new synthetic approach towards adriamycin
DHR BARTON, CC DAWES, G FRANCESCHI, M FOGLIO, SV LEY, PD MAGNUS, WL MITCHELL, A TEMPERELLI - J CHEM SOC PERK T 1 (
1980), 643
(DOI:
10.1039/p19800000643)
The crystal structure of 3-epicaryoptin and the reversal of the currently accepted absolute configuration of clerodin
D ROGERS, GG UNAL, DJ WILLIAMS, SV LEY, GA SIM, BS JOSHI, KR RAVINDRANATH - Journal of the Chemical Society, Chemical Communications (
1979), 97
(DOI:
10.1039/c39790000097)
Synthesis of a substituted cis-decalin as a potential insect antifeedant
WP JACKSON, SV LEY - Journal of the Chemical Society, Chemical Communications (
1979), 732
(DOI:
10.1039/c39790000732)
Preparation of episulphides from alkenes via succinimide-N-sulphenyl chloride or phthalimide-N-sulphenyl chloride adducts
MU BOMBALA, SV LEY - J CHEM SOC PERK T 1 (
1979), 3013
(DOI:
10.1039/p19790003013)
Preparation of aldehydes and ketones by oxidation of benzylic hydrocarbons with benzeneseleninic anhydride
DHR BARTON, RAHF HUI, DJ LESTER, SV LEY - Tetrahedron Letters (1979) 20, 3331
Isolation, Characterisation and Oxidation of Isomeric Ferrelactone Complexes.
GD ANNIS, SV LEY, R SIVARAMAKRISHNAN, AM ATKINSON, D ROGERS, DJ WILLIAMS - Journal of Organometallic Chemistry (
1979)
182, C11
(DOI:
10.1016/S0022-328X(00)85886-6)
