In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
Thermal rearrangement reactions of tricarbonyliron lactone complexes
GD ANNIS, SV LEY, CR SELF, R SIVARAMAKRISHNAN, DJ WILLIAMS - J CHEM SOC PERK T 1 (
1982), 1355
(DOI:
10.1039/p19820001355)
Synthesis of polyoxygenated trans-decalins as potential insect antifeedants
SV LEY, D NEUHAUS, NS SIMPKINS, AJ WHITTLE - J CHEM SOC PERK T 1 (
1982), 2157
(DOI:
10.1039/p19820002157)
SYNTHESIS OF METHYL-1,6-DIOXASPIRO[4,5]DECANES USING ORGANOSELENIUM MEDIATED CYCLIZATION REACTIONS
SV LEY, B LYGO - Tetrahedron Letters (
1982)
23, 4625
(DOI:
10.1016/S0040-4039(00)85671-3)
SYNTHESIS OF (CIS-6-METHYLTETRAHYDROPYRAN-2-YL)ACETIC ACID INVOLVING THE USE OF AN ORGANOSELENIUM-MEDIATED CYCLIZATION REACTION
SV LEY, B LYGO, H MOLINES, JA MORTON - Journal of the Chemical Society, Chemical Communications (
1982), 1251
(DOI:
10.1039/c39820001251)
Oxidation of benzylic hydrocarbons with benzeneseleninic anhydride and related reactions
DHR BARTON, RAHF HUI, SV LEY - J CHEM SOC PERK T 1 (
1982), 2179
(DOI:
10.1039/p19820002179)
DEHYDROGENATION OF LACTONES USING BENZENESELENINIC ANHYDRIDE - X-RAY CRYSTAL-STRUCTURE OF 3-BETA-ACETOXY-14-ALPHA-HYDROXY-17A-OXA-D-HOMO-5-ALPHA-ANDROST-15-EN-17-ONE
DHR BARTON, RAHF HUI, SV LEY - J CHEM SOC PERK T 1 (
1982), 1919
(DOI:
10.1039/p19820001919)
A short synthesis of (±)-hirsutene involving the use of an organoselenium-mediated cyclization reaction
SV LEY, PJ MURRAY - Journal of the Chemical Society, Chemical Communications (
1982), 1252
(DOI:
10.1039/c39820001252)
A practical catalytic method for the preparation of steroidal 1,4-dien-3-ones by oxygen atom transfer from iodoxybenzene to diphenyl diselenide
DHR BARTON, CRA GODFREY, JW MORZYCKI, WB MOTHERWELL, SV LEY - J CHEM SOC PERK T 1 (
1982), 1947
(DOI:
10.1039/p19820001947)
An unexpected rearrangement of 4-alkylaminoindoles
SV LEY, RA PORTER - Journal of the Chemical Society, Chemical Communications (
1982), 1356
(DOI:
10.1039/c39820001356)
A conformational study of elaiophylin by X-ray crystallography and difference 1H NMR methods; observation of a selective sign reversal of the nuclear overhauser effect
SV LEY, D NEUHAUS, DJ WILLIAMS - Tetrahedron Letters (
1982)
23, 1207
(DOI:
10.1016/S0040-4039(00)87061-6)
