In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
Synthesis of euryfuran, valdiviolide, and confertifolin
SV LEY, M MAHON - Tetrahedron Letters (
1981)
22, 4747
(DOI:
10.1016/S0040-4039(01)83030-6)
Synthesis of cinnamolide and polygodial
SC HOWELL, SV LEY, M MAHON, PA WORTHINGTON - Journal of the Chemical Society, Chemical Communications (
1981), 507
(DOI:
10.1039/c39810000507)
Synthesis of a trans-decalin as a potential insect antifeedant
SV LEY, NS SIMPKINS, AJ WHITTLE - Journal of the Chemical Society, Chemical Communications (
1981), 1001
(DOI:
10.1039/c39810001001)
Preparation of lactones via tricarbonyliron-lactone complexes
GD ANNIS, SV LEY, CR SELF, R SIVARAMAKRISHNAN - J CHEM SOC PERK T 1 (
1981), 270
(DOI:
10.1039/p19810000270)
Oxygen atom transfer from iodylbenzene to diphenyl diselenide - A convenient method for dehydrogenation of steroidal 3-ketones
DHR BARTON, JW MORZYCKI, WB MOTHERWELL, SV LEY - Journal of the Chemical Society, Chemical Communications (
1981), 1044
(DOI:
10.1039/c39810001044)
Oxidation of phenols, pyrocatechols, and hydroquinones to ortho-quinones using benzeneseleninic anhydride
DHR BARTON, AG BREWSTER, SV LEY, CM READ, MN ROSENFELD - J CHEM SOC PERK T 1 (
1981), 1473
(DOI:
10.1039/p19810001473)
On the reaction of thioacetals with sulphuryl chloride
PC BULMANPAGE, SV LEY, JA MORTON, DJ WILLIAMS - J CHEM SOC PERK T 1 (
1981), 457
(DOI:
10.1039/p19810000457)
EXPERIMENTS ON THE SYNTHESIS OF TETRACYCLINE .16. IMPROVED PHOTOCYCLIC PREPARATION OF 12-KETO-DERIVATIVES AND THEIR DEPROTECTION USING BENZENESELENINIC ANHYDRIDE
DHR BARTON, MT BIELSKA, JM CARDOSO, NJ CUSSANS, SV LEY - J CHEM SOC PERK T 1 (
1981), 1840
(DOI:
10.1039/p19810001840)
Erratum: Selenium-mediated cyclization reactions of alkenyl-substituted β-ketoesters (Journal of the Chemical Society, Chemical Communications (1980) (1174))
WP Jackson, SV Ley, AJ Whittle - Journal of the Chemical Society, Chemical Communications (1981), 728
DIARYL TELLUROXIDES AS NEW MILD OXIDIZING REAGENTS
SV LEY, CA MEERHOLZ, DHR BARTON - TETRAHEDRON (
1981)
37, 213
(DOI:
10.1016/0040-4020(81)85057-0)
