Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
New building blocks for efficient and highly diastereoselective polyol production - Synthesis and utility of (R ',R ',S,S) and (S ',S ',R,R)-2,3-butane diacetal protected butane tetrol derivatives
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1999)
1627
(doi: 10.1039/a902734c)
Total synthesis of the cholesterol biosynthesis inhibitor 1233A via a (pi-allyl)tricarbonyliron lactone complex
J CHEM SOC PERK T 1
(1999)
1917
(doi: 10.1039/a903641e)
Synthesis of the alkaloids (+/-)-oxomaritidine and (+/-)-epimaritidine using an orchestrated multi-step sequence of polymer supported reagents
Journal of the Chemical Society Perkin Transactions 1
(1999)
1251
(doi: 10.1039/a901798d)
Tritiated dihydroazadirachtin binging to Schistocerca gregaria testes and Spodoptera Sf9 cells suggests a similar cellular mechanism of action for azadirachtin
AZADIRACHTA INDICA A. JUSS.
(1999)
247
Dispiroketals in synthesis. Part 25. Further reactions of dispiroketal protected glycolate to afford optically active 1,2,3,4-tetraols
J CHEM SOC PERK T 1
(1999)
1647
(doi: 10.1039/a900951e)
Chemistry of Insect Antifeedants from Azadirachta indica (Part 22): Functionalisation of the Decalin Fragment of Azadirachtin via a Claisen Rearrangement Reaction
Synlett
(1999)
1999
1295
(doi: 10.1055/s-1999-2802)
Clean synthesis of a-bromo ketones and their utilisation in the synthesis of 2-aIkoxy-2,3-dihydro-2-aryl-l,4-benzodioxanes, 2-amino-4-aryI-l,3-thiazoles and piperidino-2-amino-l,3-thiazoles using polymer-supported reagents
Journal of the Chemical Society Perkin Transactions 1
(1999)
2425
(doi: 10.1039/a905616e)
Recent studies on the use of MPA and MTPA in the determination of the absolute configuration of secondary alcohols by 1H NMR
Chemtracts
(1999)
12
539
Preparation of desymmetrised meso-tartrate derivatives-synthesis and utility of (R,R,R,S)-2,3-butane diacetal protected dimethyl tartrate
Journal of the Chemical Society, Perkin Transactions 1
(1999)
1631
(doi: 10.1039/a902733e)
A general and efficient procedure for the preparation of enantiopure a/rf/-l,2-diols-synthesis and utility of (Rr ,R',S,K)-2,3-butam diacetal protected butane tetrol
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1999)
1635
(doi: 10.1039/a902732g)
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