In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
A NEW ROUTE TO SPIRO-KETALS USING THE HORNER-WITTIG REACTION OF 2-DIPHENYLPHOSPHINOXY CYCLIC ETHERS
SV LEY, B LYGO - Tetrahedron Letters (
1984)
25, 113
(DOI:
10.1016/S0040-4039(01)91163-3)
TOTAL SYNTHESIS OF THE STRUCTURALLY UNIQUE IONOPHORE ANTIBIOTIC X-14547-A
MP EDWARDS, SV LEY, SG LISTER, BD PALMER - Journal of the Chemical Society - Series Chemical Communications (
1983)
No. 11, 630
(DOI:
10.1039/c39830000630)
The total synthesis of the clerodane diterpene insect antifeedant ajugarin I
SV LEY, NS SIMPKINS, AJ WHITTLE - Journal of the Chemical Society - Series Chemical Communications (
1983)
No. 9, 503
(DOI:
10.1039/c39830000503)
The Diels-Alder route to drimane related sesquiterpenes; synthesis of cinnamolide, polygodial, isodrimeninol, drimenin and warburganal
DM HOLLINSHEAD, SC HOWELL, SV LEY, M MAHON, NM RATCLIFFE, PA WORTHINGTON - J CHEM SOC PERK T 1 (
1983), 1579
(DOI:
10.1039/p19830001579)
Synthesis of β-lactams from π-allyltricarbonyliron (lactone) complexes
GD ANNIS, EM HEBBLETHWAITE, ST HODGSON, DM HOLLINSHEAD, SV LEY - J CHEM SOC PERK T 1 (
1983), 2851
(DOI:
10.1039/p19830002851)
Synthesis of the drimane-related sesquiterpenes euryfuran, confertifolin, and valdiviolide
SV LEY, M MAHON - J CHEM SOC PERK T 1 (
1983), 1379
(DOI:
10.1039/p19830001379)
STEREOCHEMISTRY OF A 5,5,10-TRIMETHYL-2-DECALONE BY PROTON NUCLEAR MAGNETIC-RESONANCE - A NEW APPLICATION OF INDOR DIFFERENCE SPECTROSCOPY
SV LEY, AJ WHITTLE, GE HAWKES - J CHEM RES-S (1983), 210
Regiospecific alkylation of β-ketothioesters and use in the synthesis of acyl-tetronic acids
PM BOOTH, CMJ FOX, SV LEY - Tetrahedron Letters (
1983)
24, 5143
(DOI:
10.1016/S0040-4039(00)94065-6)
Peterson olefination using phenylsulphonyltrimethylsilylmethane. A new preparation of vinylic sulphones
SV LEY, NS SIMPKINS - Journal of the Chemical Society, Chemical Communications (
1983), 1281
(DOI:
10.1039/c39830001281)
The X-ray structure and absolute configuration of insect antifeedant clerodane diterpenoids from Teucrium africanum
JR HANSON, DEA RIVETT, SV LEY, DJ WILLIAMS - J CHEM SOC PERK T 1 (
1982), 1005
(DOI:
10.1039/p19820001005)
