Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

pi-allyltricarbonyliron lactone complexes in a diastereoselective Mukaiyama aldol reaction.

SVJ Ley, EA Wright

ABSTR PAP AM CHEM S

(1999)

218

U51

Use of the Potassium Ion as a Template for the Selective Derivatization of the Antibiotic X-206

AC O'Sulliva, F Struber, SV Ley

Journal of Organic Chemistry

(1999)

64

6252

(doi: 10.1021/jo9903151)

Synthesis of an array of potential matrix metalloproteinase inhibitors using a sequence of polymer-supported reagents

M Caldarelli, J Habermann, SV Ley

Bioorganic & Medicinal Chemistry Letters

(1999)

9

2049

(doi: 10.1016/S0960-894X(99)00311-X)

Actions of azadirachtin, a plant allelochemical, against insects

AJ Mordue, MSJ Simmonds, SV Ley, WM Blaney, W Mordue, M Nasiruddin, AJ Nisbet

Pesticide Science

(1999)

54

277

(doi: 10.1002/(SICI)1096-9063(1998110)54:3<277::AID-PS801>3.0.CO;2-I)

Molybdenum(II)-Catalyzed Allylation of Electron-Rich Aromatics and Heteroaromatics

AV Malkov, SL Davis, IR Baxendale, WL Mitchell, P Kocovský

The Journal of Organic Chemistry

(1999)

64

2751

(doi: 10.1021/jo982178y)

Molybdenum(II)- and Tungsten(II)-Catalyzed Allylic Substitution.

AV Malkov, IR Baxendale, D Dvorák, DJ Mansfield, P Kocovský

The Journal of organic chemistry

(1999)

64

2737

(doi: 10.1021/jo9821776)

1,7-Induction of chirality in Mukaiyama aldol reactions using π- allyltricarbonyliron lactone and lactam complexes as chiral templates

SV Ley, LR Cox, B Middleton, JM Worrall

Tetrahedron

(1999)

55

3515

(doi: 10.1016/S0040-4020(98)01159-4)

Clean five-step synthesis of an array of 1,2,3,4-tetra-substituted pyrroles using polymer-supported reagents

M Caldarelli, J Habermann, SV Ley

Journal of the Chemical Society Perkin Transactions 1

(1999)

107

(doi: 10.1039/a809345h)

Rapid Assembly of Oligosaccharides: Total Synthesis of a Glycosylphosphatidylinositol Anchor of Trypanosoma brucei

DK Baeschlin, AR Chaperon, V Charbonneau, LG Green, SV Ley, U Lücking, E Walther

Angew Chem Int Ed Engl

(1999)

37

3423

(doi: 10.1002/(SICI)1521-3773(19981231)37:24<3423::AID-ANIE3423>3.0.CO;2-I)

Nitrogen atom transfer from a novel nitridomanganese complex for the amination of silyl enol ether and glycal derivatives

SV Ley, DJ Dixon

Chemtracts

(1999)

12

27