In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
Natural product synthesis using π-allyltricarbonyliron lactone complexes: Synthesis of parasorbic acid, the carpenter bee pheromone and malyngolide
AM HORTON, SV LEY - Journal of Organometallic Chemistry (
1985)
285, C17
(DOI:
10.1016/0022-328X(85)87394-0)
π-Allyltricarbonyliron lactone complexes in synthesis: Application to the synthesis of the β-lactam antibiotic (+)- thienamycin
ST HODGSON, DM HOLLINSHEAD, SV LEY - Journal of the Chemical Society - Series Chemical Communications (
1984)
NO. 8, 494
(DOI:
10.1039/c39840000494)
Total synthesis of the ionophore antibiotic X-14547A (indanomycin)
MP EDWARDS, SV LEY, SG LISTER, BD PALMER, DJ WILLIAMS - Journal of Organic Chemistry (
1984)
49, 3503
(DOI:
10.1021/jo00193a014)
THE USE OF "3-ACETOXY-1-TRIMETHYLSILYLBUTADIENE IN THE SYNTHESIS OF ANTHRACYCLINONE DERIVATIVES
PC BULMANPAGE, SV LEY - J CHEM SOC PERK T 1 (
1984), 1847
(DOI:
10.1039/p19840001847)
Synthesis of the spiroacetal unit related to the avermectins and milbemycins
J GODOY, SV LEY, B LYGO - Journal of the Chemical Society, Chemical Communications (
1984), 1381
(DOI:
10.1039/c39840001381)
Synthesis of spiroacetals using organoselenium-mediated cyclisation reactions. X-Ray molecular structure of (2S,8R)-8-methyl-2-phenyl-1,7- dioxaspiro-[5.5]undecan-4(R)-ol
AM DOHERTY, SV LEY, B LYGO, DJ WILLIAMS - J CHEM SOC PERK T 1 (
1984), 1371
(DOI:
10.1039/p19840001371)
Synthesis of (±)-cis-6-methyltetrahydropyran-2-ylacetic acid, a natural product from viverra civetta, using organoselenium-mediated cyclisation reactions
SV LEY, B LYGO, H MOLINES - J CHEM SOC PERK T 1 (
1984), 2403
(DOI:
10.1039/p19840002403)
Oxo complexes of ruthenium(VI) and (VII) as organic oxidants
G GREEN, WP GRIFFITH, DM HOLLINSHEAD, SV LEY, M SCHRODER - J CHEM SOC PERK T 1 (
1984), 681
(DOI:
10.1039/p19840000681)
NOVEL REARRANGEMENT OF THE IONOPHORE ANTIBIOTIC X-14547A (INDANOMYCIN) AND RELATED DERIVATIVES INDUCED BY LITHIUM TETRAFLUOROBORATE
MP EDWARDS, SV LEY - J CHEM SOC PERK T 1 (
1984), 1761
(DOI:
10.1039/p19840001761)
FE2(CO)9 IN TETRAHYDROFURAN OR UNDER SONOCHEMICAL CONDITIONS AS CONVENIENT PRACTICAL ROUTES TO PI-ALLYLTRICARBONYLIRON LACTONE COMPLEXES
AM HORTON, DM HOLLINSHEAD, SV LEY - Tetrahedron (
1984)
40, 1737
(DOI:
10.1016/S0040-4020(01)91124-X)
