In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
The use of t-butyl acetothioacetate as a route to bis-β-ketomacrolides
CMJ FOX, SV LEY, AMZ SLAWIN, DJ WILLIAMS - Journal of the Chemical Society, Chemical Communications (
1985), 1805
(DOI:
10.1039/c39850001805)
WITTIG AND HORNER-WITTIG COUPLING REACTIONS OF 2-SUBSTITUTED CYCLIC ETHERS AND THEIR APPLICATION TO SPIROKETAL SYNTHESIS
SV LEY, B LYGO, HM ORGAN, A WONNACOTT - Tetrahedron (
1985)
41, 3825
(DOI:
10.1016/S0040-4020(01)91403-6)
USE OF PI-ALLYLTRICARBONYLIRON LACTAM COMPLEXES IN THE PREPARATION OF NOCARDICIN DERIVATIVES - SYNTHESIS OF (-)-3-OXO-1-[(PARA-BENZYLOXYPHENYL)-BENZYLOXYCARBONYLMETHYL]AZETIDIN-2-ONE
ST HODGSON, DM HOLLINSHEAD, SV LEY, CMR LOW, DJ WILLIAMS - J CHEM SOC PERK T 1 (
1985), 2375
(DOI:
10.1039/p19850002375)
Total synthesis of the sesquiterpene (±)-hirsutene using an organoselenium-mediated cyclization reaction
SV LEY, PJ MURRAY, BD PALMER - Tetrahedron (
1985)
41, 4765
(DOI:
10.1016/S0040-4020(01)96715-8)
SYNTHETIC APPLICATIONS OF YNES, ENES AND ONES - ORGANOSELENIUM-MEDIATED CYCLIZATION REACTIONS IN ORGANIC-SYNTHESIS
SV LEY - CHEMISTRY & INDUSTRY (1985), 101
Synthesis of the β-lactam antibiotic (+)-thienamycin via an intermediate π-allyltricarbonyliron lactone complex
ST HODGSON, DM HOLLINSHEAD, SV LEY - Tetrahedron (
1985)
41, 5871
(DOI:
10.1016/S0040-4020(01)91426-7)
Synthesis of the northern hemisphere of the milbemycins using a new strategy for the formation of the C-15 to C-16 bond
D CULSHAW, P GRICE, SV LEY, GA STRANGE - Tetrahedron Letters (
1985)
26, 5837
(DOI:
10.1016/S0040-4039(00)98940-8)
Structural reappraisal of the limonoid insect antifeedant azadirachtin
JN BILTON, HB BROUGHTON, SV LEY, Z LIDERT, ED MORGAN, HS RZEPA, RN SHEPPARD - Journal of the Chemical Society, Chemical Communications (
1985), 968
(DOI:
10.1039/c39850000968)
Preparation of vinylic sulphones by Peterson olefination using phenyl trimethylsilylmethyl sulphone
D CRAIG, SV LEY, NS SIMPKINS, GH WHITHAM, MJ PRIOR - J CHEM SOC PERK T 1 (
1985), 1949
(DOI:
10.1039/p19850001949)
Preparation and reactions of 2-benzenesulphonyltetrahydropyran
SV LEY, B LYGO, A WONNACOTT - Tetrahedron Letters (
1985)
26, 535
(DOI:
10.1016/S0040-4039(00)61931-7)
