Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Clean and efficient synthesis of azo dyes using polymer-supported reagents
Green Chemistry
(2000)
2
43
(doi: 10.1039/b000816h)
Untitled - Comment
CHEMISTRY IN BRITAIN
(2000)
36
3
Parallel solution-phase syntheses of functionalised bicyclo[2.2.2]octanes: Generation of a library using orchestrated multistep sequences of polymer-supported reagents and sequesterants
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(2000)
3645
(doi: 10.1039/b003129l)
Methyl 2,3-O-(6,6'-octahydro-6,6'-BI-2H-PYRAN-2,2'-DIYL)-α-D-galactopyranoside [ α-D-Galactopyranoside, methyl, 2,3-O-(octahydro[2,2'-bi-2H-pyran]-2,2'-diyl-, [2(2R,2'R)-] ]
Organic Syntheses
(2000)
77
212
(doi: 10.15227/orgsyn.077.0212)
A Short and Efficient Stereoselective Synthesis of the Potent 5-Lipoxygenase Inhibitor CMI-977
Synthetic Communications
(2000)
30
1955
(doi: 10.1080/00397910008087245)
1,2-Diacetals in synthesis: total synthesis of a glycosylphosphatidylinositol anchor of Trypanosoma brucei.
Chemistry A European Journal
(1999)
6
172
Synthesis of Glycans from the Glycodelins: Two Undeca-, Two Deca-, Three Nona-, an Octa- and a Heptasaccharide
Chemistry A European Journal
(1999)
5
3326
Synthesis of Glycans from the Glycodelins: Two Undeca‐, Two Deca‐, Three Nona‐, an Octa‐ and a Heptasaccharide
Chemistry A European Journal
(1999)
5
3326
Modified mesoporous silicate MCM-41 materials: immobilised perruthenate - a new highly active heterogeneous oxidation catalyst for clean organic synthesis using molecular oxygen
Chemical Communications
(1999)
1907
(doi: 10.1039/a906354d)
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