In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
Application of ultrasound to the preparation of tricarbonyliron diene complexes
SV LEY, CMR LOW, AD WHITE - Journal of Organometallic Chemistry (
1986)
302, C13
(DOI:
10.1016/0022-328X(86)80072-9)
Synthetic approaches to the teleocidin-related tumour promoters: A total synthesis of (±)-indolactam V
SE DELASZLO, SV LEY, RA PORTER - Journal of the Chemical Society - Series Chemical Communications (
1986)
No. 4, 344
(DOI:
10.1039/c39860000344)
The synthesis of trisubstituted tetrahydrofurans via the use of an organoselenium-mediated cyclisation reaction
G BRUSSANI, SV LEY, JL WRIGHT, DJ WILLIAMS - J CHEM SOC PERK T 1 (
1986), 303
(DOI:
10.1039/p19860000303)
X-ray crystallographic structure determination of detigloyldihydroazadirachtin and reassignment of the structure of the limonoid insect antifeedant azadirachtin
HB BROUGHTON, SV LEY, AMZ SLAWIN, DJ WILLIAMS, ED MORGAN - Journal of the Chemical Society, Chemical Communications (
1986)
1, 46
(DOI:
10.1039/c39860000046)
Ultrasonic formation and reactions of sodium phenylselenide
SV LEY, IA ONEIL, CMR LOW - Tetrahedron (
1986)
42, 5363
(DOI:
10.1016/S0040-4020(01)82086-X)
Total synthesis of the insect antifeedant ajugarin I and degradation studies of related clerodane diterpenes
PS JONES, SV LEY, NS SIMPKINS, AJ WHITTLE - Tetrahedron (
1986)
42, 6519
(DOI:
10.1016/S0040-4020(01)88114-X)
Synthetic studies towards the acyltetronic acid ionophore M 139603
AM DOHERTY, SV LEY - Tetrahedron Letters (
1986)
27, 105
(DOI:
10.1016/S0040-4039(00)83953-2)
Preparation of spiroketals by reaction of anions from 2-benzenesulphonyltetrahydropyrans with epoxides: Synthesis of the C-11 to C-25 fragment of the milbemycins
C GRECK, P GRICE, SV LEY, A WONNACOTT - Tetrahedron Letters (
1986)
27, 5277
(DOI:
10.1016/S0040-4039(00)85190-4)
Preparation of 2-substituted pyrroles and indoles by regioselective alkylation and deprotection of 1-(2-trimethylsilylethoxymethyl)pyrrole and 1-(2-trimethylsilylethoxymethyl) indole
MP EDWARDS, AM DOHERTY, SV LEY, HM ORGAN - Tetrahedron (
1986)
42, 3723
(DOI:
10.1016/S0040-4020(01)87342-7)
Alkylation reactions of anions derived from 2-benzenesulphonyl tetrahydropyran and their application to spiroketal syntiesis
SV LEY, B LYGO, F STERNFELD, A WONNACOTT - Tetrahedron (
1986)
42, 4333
(DOI:
10.1016/S0040-4020(01)87660-2)
