In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
X-ray crystallographic structure determination of detigloyldihydroazadirachtin and reassignment of the structure of the limonoid insect antifeedant azadirachtin
HB BROUGHTON, SV LEY, AMZ SLAWIN, DJ WILLIAMS, ED MORGAN - Journal of the Chemical Society Chemical Communications (
1986)
1, 46
(DOI:
10.1039/c39860000046)
Ultrasonic formation and reactions of sodium phenylselenide
SV LEY, IA ONEIL, CMR LOW - Tetrahedron (
1986)
42, 5363
(DOI:
10.1016/S0040-4020(01)82086-X)
Total synthesis of the insect antifeedant ajugarin I and degradation studies of related clerodane diterpenes
PS JONES, SV LEY, NS SIMPKINS, AJ WHITTLE - Tetrahedron (
1986)
42, 6519
(DOI:
10.1016/S0040-4020(01)88114-X)
Synthetic studies towards the acyltetronic acid ionophore M 139603
AM DOHERTY, SV LEY - Tetrahedron Letters (
1986)
27, 105
(DOI:
10.1016/S0040-4039(00)83953-2)
Preparation of spiroketals by reaction of anions from 2-benzenesulphonyltetrahydropyrans with epoxides: Synthesis of the C-11 to C-25 fragment of the milbemycins
C GRECK, P GRICE, SV LEY, A WONNACOTT - Tetrahedron Letters (1986) 27, 5277
Preparation of 2-substituted pyrroles and indoles by regioselective alkylation and deprotection of 1-(2-trimethylsilylethoxymethyl)pyrrole and 1-(2-trimethylsilylethoxymethyl) indole
MP EDWARDS, AM DOHERTY, SV LEY, HM ORGAN - Tetrahedron (
1986)
42, 3723
(DOI:
10.1016/S0040-4020(01)87342-7)
Alkylation reactions of anions derived from 2-benzenesulphonyl tetrahydropyran and their application to spiroketal syntiesis
SV LEY, B LYGO, F STERNFELD, A WONNACOTT - Tetrahedron (
1986)
42, 4333
(DOI:
10.1016/S0040-4020(01)87660-2)
The use of t-butyl acetothioacetate as a route to bis-β-ketomacrolides
CMJ FOX, SV LEY, AMZ SLAWIN, DJ WILLIAMS - Journal of the Chemical Society, Chemical Communications (
1985), 1805
(DOI:
10.1039/c39850001805)
WITTIG AND HORNER-WITTIG COUPLING REACTIONS OF 2-SUBSTITUTED CYCLIC ETHERS AND THEIR APPLICATION TO SPIROKETAL SYNTHESIS
SV LEY, B LYGO, HM ORGAN, A WONNACOTT - Tetrahedron (
1985)
41, 3825
(DOI:
10.1016/S0040-4020(01)91403-6)
USE OF PI-ALLYLTRICARBONYLIRON LACTAM COMPLEXES IN THE PREPARATION OF NOCARDICIN DERIVATIVES - SYNTHESIS OF (-)-3-OXO-1-[(PARA-BENZYLOXYPHENYL)-BENZYLOXYCARBONYLMETHYL]AZETIDIN-2-ONE
ST HODGSON, DM HOLLINSHEAD, SV LEY, CMR LOW, DJ WILLIAMS - J CHEM SOC PERK T 1 (
1985), 2375
(DOI:
10.1039/p19850002375)
