Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

A short stereoselective total synthesis of the fusarium toxin equisetin.

LT Burke, DJ Dixon, SV Ley, F Rodríguez

Org Lett

(2000)

2

3611

(doi: 10.1021/ol006493u)

The Total Synthesis of the Annonaceous Acetogenin, Muricatetrocin C

DJ Dixon, SV Ley, DJ Reynolds

Angewandte Chemie

(2000)

39

3622

(doi: 10.1002/1521-3773(20001016)39:20<3622::AID-ANIE3622>3.0.CO;2-H)

The Total Synthesis of the Annonaceous Acetogenin, Muricatetrocin C

DJ Dixon, SV Ley, DJ Reynolds

Angewandte Chemie (International ed. in English)

(2000)

39

3622

(doi: 10.1002/1521-3773(20001016)39:20<3622::aid-anie3622>3.0.co;2-h)

Chemoenzymatic synthesis of l-galactosylated dimeric Sialyl Lewis X structures employing α-1,3-fucosyltransferase V

A Düffels, LG Green, R Lenz, SV Ley, SP Vincent, CH Wong

Bioorganic & medicinal chemistry

(2000)

8

2519

(doi: 10.1016/s0968-0896(00)00187-5)

Polymer-supported reagents for multi-step organic synthesis: Application to the synthesis of sildenafil

IR Baxendale, SV Ley

Bioorganic & Medicinal Chemistry Letters

(2000)

10

1983

(doi: 10.1016/s0960-894x(00)00383-8)

Combined Application of Analytical Techniques for the Characterization of Polymer Supported Species

P Grice, AG Leach, SV Ley, A Massi, DM Mynett

ACS Combinatorial Science

(2000)

2

491

(doi: 10.1021/cc000021p)

Chemo-enzymatic synthesis of fluorinated sugar nucleotide: Useful mechanistic probes for glycosyltransferases

MD Burkart, SP Vincent, A Düffels, BW Murray, SV Ley, CH Wong

Bioorganic & Medicinal Chemistry

(2000)

8

1937

(doi: 10.1016/s0968-0896(00)00139-5)

Protecting groups: Effects on reactivity, glycosylation stereoselectivity, and coupling efficiency

LG Green, SV Ley, B Ernst, GW Hart, P Sinaý

(2000)

1-4

427

(doi: 10.1002/9783527618255.ch17)

Synthesis of High‐Mannose Type Neoglycolipids: Active Targeting of Liposomes to Macrophages in Gene Therapy

A Düffels, LG Green, SV Ley, AD Miller

Chemistry A European Journal

(2000)

6

1416

(doi: 10.1002/(sici)1521-3765(20000417)6:8<1416::aid-chem1416>3.0.co;2-o)

Pinene-derived bipyridine ligands (PINDY) in asymmetric catalysis.

AV Malkov, IR Baxendale, M Bella, V Langer, P Kocovsky

ABSTR PAP AM CHEM S

(2000)

219

U132