In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
Synthesis of a hydroxy dihydrofuran acetal related to azadirachtin: A potent insect antifeedant
SV LEY, D SANTAFIANOS, WM BLANEY, MSJ SIMMONDS - Tetrahedron Letters (
1987)
28, 221
(DOI:
10.1016/S0040-4039(00)95691-0)
Synthesis of a hydroxy dihydrofuran acetal related to azadirachtin: A potent insect antifeedant
SV Ley, D Santafianos, WM Blaney, MSJ Simmonds - Tetrahedron Letters (
1987)
28, 1595
(DOI:
10.1016/S0040-4039(00)95369-3)
Progress towards avermectins and milbemycins
SV LEY - Pesticide Science (
1987)
18, 153
(DOI:
10.1002/ps.2780180210)
PREPARATION OF TERT-BUTYL 4-DIETHYLPHOSPHONO-3-OXOBUTANETHIOATE AND USE IN THE SYNTHESIS OF (E)-4-ALKENYL-3-OXOESTERS AND MACROLIDES
SV LEY, PR WOODWARD - Tetrahedron Letters (
1987)
28, 345
(DOI:
10.1016/S0040-4039(00)95725-3)
Preparation of acyltetronic acids using t-butyl acetothioacetate: Total synthesis of the fungal metabolites carolic, carlosic, and carlic acids
PM BOOTH, CMJ FOX, SV LEY - J CHEM SOC PERK T 1 (
1987), 121
(DOI:
10.1039/p19870000121)
MICROBIAL OXIDATION IN SYNTHESIS - A 6 STEP PREPARATION OF (+/-)-PINITOL FROM BENZENE
SV LEY, F STERNFELD, S TAYLOR - Tetrahedron Letters (
1987)
28, 225
(DOI:
10.1016/S0040-4039(00)95692-2)
Development of a synthetic route towards milbemycin β1: Preparation of an advanced model system.
NJ ANTHONY, P GRICE, SV LEY - Tetrahedron Letters (
1987)
28, 5763
(DOI:
10.1016/S0040-4039(00)96835-7)
CORRECTION
SV LEY - TETRAHEDRON LETT (1987) 28, 1594
An x-ray crystallographic, mass spectroscopic, and NMR study of the limonoid insect antifeedant azadirachtin and related derivatives
JN BILTON, HB BROUGHTON, PS JONES, SV LEY, Z LIDERT, ED MORGAN, HS RZEPA, RN SHEPPARD, AMZ SLAWIN, DJ WILLIAMS - Tetrahedron (
1987)
43, 2805
(DOI:
10.1016/S0040-4020(01)86886-1)
A conformational study of bafilomycin A1 by x-ray crystallography and nmr techniques
GH BAKER, PJ BROWN, RJJ DORGAN, JR EVERETT, SV LEY, AMZ SLAWIN, DJ WILLIAMS - Tetrahedron Letters (
1987)
28, 5565
(DOI:
10.1016/S0040-4039(00)96783-2)
