In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
Chemistry of insect antifeedants from azadirachta indica (part 3): reactions on the C-22,23 enol ether double bond of azadirachtin and conversion to 22,23-dihydro-23-β-methoxyazadirachtin.
SV LEY, JC ANDERSON, WM BLANEY, Z LIDERT, ED MORGAN, NG ROBINSON, MSJ SIMMONDS - Tetrahedron Letters (
1988)
29, 5433
(DOI:
10.1016/S0040-4039(00)82888-9)
Chemistry of insect antifeedants from azadirachta indica (part 2): Synthesis of a polyoxygenated decalin with limonoid structural homology.
MG BRASCA, HB BROUGHTON, D CRAIG, SV LEY, AA SOMOVILLA, PL TOOGOOD - Tetrahedron Letters (
1988)
29, 1853
(DOI:
10.1016/S0040-4039(00)82062-6)
Chemistry of insect antifeedants from azadirachta indica (part 1): Conversion from the azadirachtin to the azadirachtinin skeletons
JN BILTON, PS JONES, SV LEY, NG ROBINSON, RN SHEPPARD - Tetrahedron Letters (
1988)
29, 1849
(DOI:
10.1016/S0040-4039(00)82061-4)
1-BENZYLINDOLE
H HEANEY, SV LEY - ORGANIC SYNTHESES (1988) 50-9, 104
Preparation and use of tetra-n-butylammonium per-ruthenate (TBAP reagent) and tetra-n-propylammonium per-ruthenate (TPAP reagent) as new catalytic oxidants for alcohols
WP GRIFFITH, SV LEY, GP WHITCOMBE, AD WHITE - Journal of the Chemical Society, Chemical Communications (
1987), 1625
(DOI:
10.1039/c39870001625)
An electrophysiological and behavioural study of insect antifeedant properties of natural and synthetic drimane-related compounds
WM BLANEY, MSJ SIMMONDS, SV LEY, RB KATZ - Physiological Entomology (
1987)
12, 281
(DOI:
10.1111/j.1365-3032.1987.tb00752.x)
Use of S-t-butyl acetothioacetate in the preparation of milbemycin seco-analogues
T CLARKE, SV LEY - J CHEM SOC PERK T 1 (
1987), 131
(DOI:
10.1039/p19870000131)
The use of β-ketothioesters for the exceptionally mild preparation of β-ketoamides
SV LEY, PR WOODWARD - Tetrahedron Letters (
1987)
28, 3019
(DOI:
10.1016/S0040-4039(00)96273-7)
Synthesis of the monocyclic nonaromatic C-1 to C-10 fragments of the milbemycins and avermectins
NJ ANTHONY, T CLARKE, AB JONES, SV LEY - Tetrahedron Letters (
1987)
28, 5755
(DOI:
10.1016/S0040-4039(00)96833-3)
SYNTHESIS OF A NOVEL 3,4-DIHYDROMILBEMYCIN ANALOG
C GRECK, P GRICE, AB JONES, SV LEY - Tetrahedron Letters (
1987)
28, 5759
(DOI:
10.1016/S0040-4039(00)96834-5)
