In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA INDICA .4. SYNTHESIS TOWARDS THE LIMONOID AZADIRACHTIN - PREPARATION OF A FUNCTIONALIZED DECALIN FRAGMENT
SV LEY, AA SOMOVILLA, HB BROUGHTON, D CRAIG, AMZ SLAWIN, PL TOOGOOD, DJ WILLIAMS - Tetrahedron (
1989)
45, 2143
(DOI:
10.1016/S0040-4020(01)80075-2)
A HIGHLY CONVERGENT TOTAL SYNTHESIS OF THE SPIROACETAL MACROLIDE (+)-MILBEMYCIN BETA-1
SV LEY, NJ ANTHONY, A ARMSTRONG, MG BRASCA, T CLARKE, D CULSHAW, C GRECK, P GRICE, AB JONES, B LYGO, A MADIN, RN SHEPPARD, AMZ SLAWIN, DJ WILLIAMS - Tetrahedron (
1989)
45, 7161
(DOI:
10.1016/S0040-4020(01)89182-1)
Organic Synthesis with Tricarbonyliron Lactone Complexes
SV LEY - Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences (
1988)
326, 633
(DOI:
10.1098/rsta.1988.0114)
Activity of drimane antifeedants and related compounds against aphids, and comparative biological effects and chemical reactivity of (-)- and (+)-polygodial
Y ASAKAWA, GW DAWSON, DC GRIFFITHS, JY LALLEMAND, SV LEY, K MORI, A MUDD, M PEZECHKLECLAIRE, JA PICKETT, H WATANABE, CM WOODCOCK, ZN ZHANG - Journal of Chemical Ecology (
1988)
14, 1845
(DOI:
10.1007/BF01013481)
Insect antifeedants: a behavioural and electrophysiological investigation of natural and synthetically derived clerodane diterpenoids
WM BLANEY, MSJ SIMMONDS, SV LEY, PS JONES - Entomologia Experimentalis et Applicata (
1988)
46, 267
(DOI:
10.1111/j.1570-7458.1988.tb01121.x)
Use of t-butyl 4-diethylphosphono-3-oxobutanethioate for tetramic acid synthesis: Total synthesis of the plasmodial pigment fuligorubin A
SV LEY, SC SMITH, PR WOODWARD - Tetrahedron Letters (
1988)
29, 5829
(DOI:
10.1016/S0040-4039(00)82204-2)
PREPARATION OF TERT-BUTYL ACETOTHIOACETATE AND USE IN THE SYNTHESIS OF 3-ACETYL-4-HYDROXY-5,5-DIMETHYLFURAN-2(5H)-ONE
CMJ FOX, SV LEY - ORGANIC SYNTHESES (1988) 66, 108
Preparation of cyclic ether acetals from 2-benzenesulphonylderivatives: a new mild glycosidation procedure
DS BROWN, SV LEY, S VILE - Tetrahedron Letters (
1988)
29, 4873
(DOI:
10.1016/S0040-4039(00)80631-0)
MICROBIAL OXIDATION IN SYNTHESIS - PREPARATION FROM BENZENE OF THE CELLULAR SECONDARY MESSENGER MYO-INOSITOL-1,4,5-TRISPHOSPHATE (IP3) AND RELATED DERIVATIVES
SV LEY, F STERNFELD - Tetrahedron Letters (
1988)
29, 5305
(DOI:
10.1016/S0040-4039(00)80744-3)
DIRECT SUBSTITUTION OF 2-BENZENESULFONYL CYCLIC ETHERS USING ORGANOZINC REAGENTS
DS BROWN, SV LEY - Tetrahedron Letters (
1988)
29, 4869
(DOI:
10.1016/S0040-4039(00)80630-9)
