Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Butane-2,3-Diacetal-Desymmetrized Glycolic Acid-A New Building Block for the Stereoselective Synthesis of Enantiopure α-Hydroxy Acids.
Angew Chem Int Ed Engl
(2001)
40
2906
Development and Application of a Carbonyl-13C-Enriched Backbone Amide Linker for Solid-Phase Reaction Monitoring
Journal of combinatorial chemistry
(2001)
3
397
(doi: 10.1021/cc010012w)
Solid-phase development of a 1-hydroxybenzotriazole linker for heterocycle synthesis using analytical constructs
Journal of combinatorial chemistry
(2001)
3
387
(doi: 10.1021/cc0100114)
New catalysts for olefin metathesis
Chemtracts
(2001)
14
88
Approaches to the total synthesis of antascomicin A.
ABSTR PAP AM CHEM S
(2001)
221
U198
Studies toward the total synthesis of rapamycin.
ABSTR PAP AM CHEM S
(2001)
221
U185
A new phase-switch method for application in organic synthesis programs employing immobilization through metal-chelated tagging
Angewandte Chemie International Edition
(2001)
40
1053
Synthesis of new chiral 2,2 '-bipyridyl-type ligands, their coordination to molybdenum(0), copper(II), and palladium(II), and application in asymmetric allylic substitution, allylic oxidation, and cyclopropanation
Organometallics
(2001)
20
673
(doi: 10.1021/om000850m)
Looking to the future
CHEMISTRY IN BRITAIN
(2001)
37
24
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