In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
TOTAL SYNTHESIS OF (+) - MILBEMYCIN BETA-1
NJ ANTHONY, A ARMSTRONG, SV LEY, A MADIN - Tetrahedron Letters (
1989)
30, 3209
(DOI:
10.1016/S0040-4039(00)99203-7)
THE STRUCTURE OF 2 NEW CLERODANE DITERPENOID POTENT INSECT ANTIFEEDANTS FROM SCUTELLARIA-WORONOWII (JUZ) - JODRELLIN-A AND JODRELLIN-B
JC ANDERSON, WM BLANEY, MD COLE, LL FELLOWS, SV LEY, RN SHEPPARD, MSJ SIMMONDS - Tetrahedron Letters (
1989)
30, 4737
(DOI:
10.1016/S0040-4039(01)80789-9)
The antifeedant activity of clerodane diterpenoids from Teucrium
MSJ SIMMONDS, WM BLANEY, SV LEY, G SAVONA, M BRUNO, B RODRIGUEZ - Phytochemistry (
1989)
28, 1069
(DOI:
10.1016/0031-9422(89)80184-0)
SUBSTITUTION-REACTIONS OF 2-BENZENESULFONYL CYCLIC ETHERS WITH SILYL ENOL ETHERS PROMOTED BY ALUMINUM TRICHLORIDE
DS BROWN, SV LEY, M BRUNO - Heterocycles (1989) 28, 773
SUBSTITUTION-REACTIONS OF 2-BENZENESULFONYL CYCLIC ETHERS WITH CARBON NUCLEOPHILES
DS BROWN, M BRUNO, RJ DAVENPORT, SV LEY - Tetrahedron (
1989)
45, 4293
(DOI:
10.1016/S0040-4020(01)81323-5)
PREPARATION OF O-METHYL 3-ACYL TETRONIC ACIDS BY THE DIRECT ACYLATION OF STANNYL TETRONATES
SV LEY, DJ WADSWORTH - Tetrahedron Letters (
1989)
30, 1001
(DOI:
10.1016/S0040-4039(00)95301-2)
PREPARATION OF BETA-KETOMACROLACTONES AND BETA-KETODIOLIDES USING S-TERT-BUTYL 3-OXOBUTANETHIOATE AND S-TERT-BUTYL 4-DIETHYLPHOSPHONO-3-OXOBUTANETHIOATE
PM BOOTH, HB BROUGHTON, MJ FORD, CMJ FOX, SV LEY, AMZ SLAWIN, DJ WILLIAMS, PR WOODWARD - Tetrahedron (
1989)
45, 7565
(DOI:
10.1016/S0040-4020(01)89218-8)
Microbial Oxidation in Synthesis: Preparation of (+)- and (-)-Pinitol from Benzene
SV LEY, F STERNFELD - Tetrahedron (
1989)
45, 3463
(DOI:
10.1016/S0040-4020(01)81025-5)
MICROBIAL OXIDATION IN SYNTHESIS - PREPARATION OF 6-DEOXY CYCLITOL ANALOGS OF MYOINOSITOL 1,4,5-TRISPHOSPHATE FROM BENZENE
SV LEY, M PARRA, AJ REDGRAVE, F STERNFELD, A VIDAL - Tetrahedron Letters (
1989)
30, 3557
(DOI:
10.1016/S0040-4039(00)99439-5)
INSECT ANTIFEEDANTS FROM AZADIRACHTA INDICA .5. CHEMICAL MODIFICATION AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF AZADIRACHTIN AND SOME RELATED LIMONOIDS
SV LEY, JC ANDERSON, WM BLANEY, PS JONES, Z LIDERT, ED MORGAN, NG ROBINSON, D SANTAFIANOS, MSJ SIMMONDS, PL TOOGOOD - Tetrahedron (
1989)
45, 5175
(DOI:
10.1016/S0040-4020(01)81095-4)
