In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
Neo-clerodane insect antifeedants from Scutellaria galericulata
MD COLE, JC ANDERSON, WM BLANEY, LE FELLOWS, SV LEY, RN SHEPPARD, MSJ SIMMONDS - Phytochemistry (
1990)
29, 1793
(DOI:
10.1016/0031-9422(90)85018-B)
Microbial oxidation in synthesis: Preparation of myo-inositol phosphates and related cyclitol derivatives from benzene
SV LEY, M PARRA, AJ REDGRAVE, F STERNFELD - Tetrahedron (
1990)
46, 4995
(DOI:
10.1016/S0040-4020(01)85605-2)
INSECT ANTIFEEDANTS
SV LEY, PL TOOGOOD - CHEMISTRY IN BRITAIN (1990) 26, 31
ENANTIOSELECTIVE SYNTHESIS OF THE C3-C11 HYDROCARBON FRAGMENT OF THE IONOPHORE ANTIBIOTIC TETRONASIN (ICI 139603)
SV LEY, GN MAW, ML TRUDELL - Tetrahedron Letters (
1990)
31, 5521
(DOI:
10.1016/S0040-4039(00)97888-2)
DIRECT SUBSTITUTION OF 2-BENZENESULFONYLPIPERIDINES AND 2-BENZENESULFONYLPYRROLIDINES BY CARBON NUCLEOPHILES - SYNTHESIS OF THE PYRROLIDINE ALKALOID RUSPOLINONE
DS BROWN, T HANSSON, SV LEY - Synlett (
1990)
1990, 48
(DOI:
10.1055/s-1990-20983)
Chemistry of insect antifeedants from azadirachta indica (part 7): Preparation of an optically pure hydroxyacetal epoxide related to azadirachtin.
JC ANDERSON, SV LEY - Tetrahedron Letters (
1990)
31, 3437
(DOI:
10.1016/S0040-4039(00)97416-1)
Chemistry of insect antifeedants from azadirachta indica (part 6): Synthesis of an optically pure acetal intermediate for potential use in the synthesis of azadirachtin and novel antifeedants.
JC ANDERSON, SV LEY - Tetrahedron Letters (
1990)
31, 431
(DOI:
10.1016/S0040-4039(00)94574-X)
Assessment of butene-1,4-diols as starting materials for the preparation of π-allyltricarbonyliron complexes
RW BATES, D DIEZMARTIN, WJ KERR, JG KNIGHT, SV LEY, A SAKELLARIDIS - Tetrahedron (
1990)
46, 4063
(DOI:
10.1016/S0040-4020(01)90541-1)
THE 1ST CRYSTAL AND MOLECULAR-STRUCTURE OF LANTHANIDE HOMODINUCLEAR MACROCYCLIC COMPLEXES SHOWING METAL METAL PAIR INTERACTIONS
IA KAHWA, S FOLKES, DJ WILLIAMS, SV LEY, CA OMAHONEY, GL MCPHERSON - Journal of the Chemical Society, Chemical Communications (
1989), 1531
(DOI:
10.1039/c39890001531)
Recent developments in natural product synthesis
SV LEY - Pure and Applied Chemistry (
1989)
61, 401
(DOI:
10.1351/pac198961030401)
