In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
TOTAL SYNTHESIS OF AVERMECTIN B1A - FINAL COUPLING REACTIONS AND THE TOTAL SYNTHESIS OF AVERMECTIN B1A AGLYCONE
A ARMSTRONG, SV LEY, A MADIN, S MUKHERJEE - Synlett (
1990)
1990, 328
(DOI:
10.1055/s-1990-21080)
Azadirachtin: structural requirements for reducing growth and increasing mortality in lepidopterous larvae
MSJ SIMMONDS, WM BLANEY, SV LEY, JC ANDERSON, PL TOOGOOD - Entomologia Experimentalis et Applicata (
1990)
55, 169
(DOI:
10.1111/j.1570-7458.1990.tb01360.x)
A SIMPLE, ONE-POT, GLYCOSIDATION PROCEDURE VIA (1-IMIDAZOLYLCARBONYL) GLYCOSIDES AND ZINC BROMIDE
MJ FORD, SV LEY - Synlett (
1990)
1990, 255
(DOI:
10.1055/s-1990-21053)
Antifeedant effects of azadirachtin and structurally related compounds on lepidopterous larvae
WM BLANEY, MSJ SIMMONDS, SV LEY, JC ANDERSON, PL TOOGOOD - Entomologia Experimentalis et Applicata (
1990)
55, 149
(DOI:
10.1111/j.1570-7458.1990.tb01358.x)
Alkenylcyclic Sulphites as Novel Precursors for the Preparation of π-Allyltricarbonyliron Lactone Complexes
M CARUSO, JG KNIGHT, SV LEY - Synlett (
1990)
1990, 224
(DOI:
10.1055/s-1990-21044)
TPAP: Tetra-n-propylammonium perruthenate, a mild and convenient oxidant for alcohols
WP Griffith, SV Ley - Aldrichimica Acta (1990) 23, 13
SYNTHESIS OF THE C12-C26 FRAGMENT OF THE ACYLTETRONIC ACID IONOPHORE ANTIBIOTIC TETRONASIN (ICI-139603)
SE DELASZLO, MJ FORD, SV LEY, GN MAW - Tetrahedron Letters (
1990)
31, 5525
(DOI:
10.1016/S0040-4039(00)97889-4)
Synthesis of antifeedants for insects: novel behaviour-modifying chemicals from plants.
SV LEY - Ciba Foundation symposium (1990) 154, 80
Synthesis of a C16-C28 spiroacetal fragment of avermectin B1a and reassignment of some 1H and 13C resonances of avermectin B1a
D DIEZMARTIN, P GRICE, HC KOLB, SV LEY, A MADIN - Tetrahedron Letters (
1990)
31, 3445
(DOI:
10.1016/S0040-4039(00)97418-5)
SYNTHESIS AND MODIFICATION OF AZADIRACHTIN AND RELATED ANTIFEEDANTS
SV LEY - RECENT ADVANCES IN THE CHEMISTRY OF INSECT CONTROL II (1990) 79, 90
