In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
SYNTHESIS OF INSECT ANTIFEEDANTS
SV LEY - PESTICIDE CHEMISTRY : ADVANCES IN INTERNATIONAL RESEARCH, DEVELOPMENT, AND LEGISLATION (1991), 97
NOVEL ROUTES TO INOSITOL PHOSPHATES USING PSEUDOMONAS-PUTIDA OXIDATION OF ARENES
SV LEY, AJ REDGRAVE, LL YEUNG - INOSITOL PHOSPHATES AND DERIVATIVES (1991) 463, 132
DIRECT SUBSTITUTION OF 2-PHENYLSULPHONYLPYRROLIDINES, 2-PHENYLSULPHONYLPIPERIDINES, 2-PHENYLSULPHONYLTETRAHYDROFURANS AND 2-PHENYLSULPHONYLTETRAHYDROPYRANS BY ALKYL ORGANOMETALLIC REAGENTS IN DICHLOROMETHANE
DS BROWN, P CHARREAU, SV LEY - SYNLETT (1990), 749
AN EFFICIENT 3-STEP SYNTHESIS OF L-(-)-OLEANDROSE FROM (S)-(-)-METHYL LACTATE
MJ FORD, SV LEY - Synlett (
1990)
1990, 771
(DOI:
10.1055/s-1990-21247)
STEREOSELECTIVE SYNTHESIS OF INOSITOL PHOSPHATES
SV LEY - Pure and Applied Chemistry (
1990)
62, 2031
(DOI:
10.1351/pac199062102031)
A new ruthenium(VI) oxidant: Preparation, X-ray crystal structure, and properties of (Ph4P)[RuO2(OAc)Cl2]
WP GRIFFITH, JM JOLLIFFE, SV LEY, DJ WILLIAMS - Journal of the Chemical Society, Chemical Communications (
1990), 1219
(DOI:
10.1039/c39900001219)
MICROBIAL OXIDATION IN SYNTHESIS - CONCISE PREPARATION OF (+)-CONDURITOL-F FROM BENZENE
SV LEY, AJ REDGRAVE - Synlett (
1990)
1990, 393
(DOI:
10.1055/s-1990-21102)
TOTAL SYNTHESIS OF AVERMECTIN B1A - SYNTHESIS OF THE CARBOHYDRATE BIS-OLEANDROSE FRAGMENT AND COUPLING TO THE AVERMECTIN B1A AGLYCONE
MJ FORD, JG KNIGHT, SV LEY, S VILE - Synlett (
1990)
1990, 331
(DOI:
10.1055/s-1990-21081)
TOTAL SYNTHESIS OF AVERMECTIN B1A - SYNTHESIS OF THE C-11-C25 SPIROACETAL FRAGMENT
D DIEZMARTIN, P GRICE, HC KOLB, SV LEY, A MADIN - Synlett (
1990)
1990, 326
(DOI:
10.1055/s-1990-21079)
TOTAL SYNTHESIS OF AVERMECTIN B1A - PLANNING OF THE SYNTHESIS AND PREPARATION OF THE C1-C10 SOUTHERN HYDROBENZOFURAN FRAGMENT
A ARMSTRONG, SV LEY - Synlett (
1990)
1990, 323
(DOI:
10.1055/s-1990-21078)
