In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
MICROBIAL OXIDATION IN SYNTHESIS - PREPARATION OF NOVEL 3-SUBSTITUTED CIS-CYCLOHEXA-3,5-DIENE-1,2-DIOL DERIVATIVES FROM (1S,2S)-3-BROMOCYCLOHEXA-3,5-DIENE-1,2-DIOL
SV LEY, AJ REDGRAVE, SC TAYLOR, S AHMED, DW RIBBONS - SYNLETT (1991), 741
A FACILE ROUTE TO IMIDAZOL-4-YL ANIONS AND THEIR REACTION WITH CARBONYL-COMPOUNDS
RM TURNER, SD LINDELL, SV LEY - Journal of Organic Chemistry (
1991)
56, 5739
(DOI:
10.1021/jo00020a002)
The total synthesis of agglomerin A and (±)-carolinic acid. A general method for the preparation of 3-acyl tetronic acids via direct acylation of O-methyl 3-stannyl tetronates
SV LEY, ML TRUDELL, DJ WADSWORTH - Tetrahedron (
1991)
47, 8285
(DOI:
10.1016/S0040-4020(01)91021-X)
Chemistry of insect antifeedants from azadirachta indica (part 8): Synthesis of hydroxydihydrofuran acetal fragments for biological evaluation and azadirachtin total synthesis studies.
JC ANDERSON, SV LEY, D SANTAFIANOS, RN SHEPPARD - Tetrahedron (
1991)
47, 6813
(DOI:
10.1016/S0040-4020(01)82332-2)
Synthesis of the β-lactone esterase inhibitor valilactone using π-allyltricarbonyliron lactone complexes
RW BATES, R FERNANDEZMORO, SV LEY - Tetrahedron Letters (
1991)
32, 2651
(DOI:
10.1016/S0040-4039(00)78809-5)
Use of Phenylsulphonylmethano Ethers in Synthesis: A New Versatile Route to Substituted Cyclic Ethers
P CHARREAU, SV LEY, TM VETTIGER, S VILE - Synlett (
1991)
1991, 415
(DOI:
10.1055/s-1991-20747)
TOTAL SYNTHESIS OF THE ANTHELMINTIC MACROLIDE AVERMECTIN B1A
SV LEY, A ARMSTRONG, D DIEZMARTIN, MJ FORD, P GRICE, JG KNIGHT, HC KOLB, A MADIN, CA MARBY, S MUKHERJEE, AN SHAW, AMZ SLAWIN, S VILE, AD WHITE, DJ WILLIAMS, M WOODS - J CHEM SOC PERK T 1 (
1991), 667
(DOI:
10.1039/p19910000667)
USE OF 2-PHENYLSULFONYL CYCLIC ETHERS IN THE PREPARATION OF TETRAHYDROPYRAN AND TETRAHYDROFURAN ACETALS AND IN SOME GLYCOSIDATION REACTIONS
DS BROWN, SV LEY, S VILE, M THOMPSON - Tetrahedron (
1991)
47, 1329
(DOI:
10.1016/S0040-4020(01)86389-4)
Substitution reactions of 2-phenylsulphonyl-piperidines and -pyrrolidines with carbon nucleophiles: Synthesis of the pyrrolidine alkaloids Norruspoline and Ruspolinone
DS BROWN, P CHARREAU, T HANSSON, SV LEY - Tetrahedron (
1991)
47, 1311
(DOI:
10.1016/S0040-4020(01)86388-2)
SYNTHESIS OF TETRAHYDROPYRAN-CONTAINING NATURAL-PRODUCTS
SV LEY - HETEROCYCLES IN BIO-ORGANIC CHEMISTRY (1991), 1
