Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Directed Syntheses of the Isomeric Dimethylcyclooctatetraenes and a Study of Their Polarographic and Alkali Metal Reduction
Journal of the American Chemical Society
(2002)
96
5806
(doi: 10.1021/ja00825a019)
Alkali metal reduction studies of cis- and trans-bicyclo[6.1.0]nona-2,4,6-trienes in liquid ammonia. Evidence for the high basicity of monohomocyclooctatetraene dianions
Journal of the American Chemical Society
(2002)
96
6670
(doi: 10.1021/ja00828a021)
An Efficient Synthesis of (-)-Triquinacene-2-carboxylic Acid
Journal of the American Chemical Society
(2002)
96
312
(doi: 10.1021/ja00808a081)
Synthesis of trifluoromethyl ketones using polymer-supported reagents
Combinatorial Chemistry & High Throughput Screening
(2002)
5
197
(doi: 10.2174/1386207024607220)
Tetracyanoethylene addition to iron tricarbonyl complexes of substituted cyclooctatetraenes. Regioselectivity considerations during formation of the 2,3,4,10-tetrahapto adducts
Journal of the American Chemical Society
(2002)
97
4658
(doi: 10.1021/ja00849a031)
A facile route to imidazol-4-yl anions and their reaction with carbonyl compounds
Journal of Organic Chemistry
(2002)
56
5739
(doi: 10.1021/jo00020a002)
Total Synthesis of the Ionophore Antibiotic X-14547A (Indanomycin)
The Journal of Organic Chemistry
(2002)
49
3503
(doi: 10.1021/jo00193a014)
Synthesis and Reducibility of Homo-2-methoxyazocines and Their Benzo-Fused Derivatives. An Examination of Heteroatomic Influences on the Possible Generation of 9C-10π Homoaromatic Dianions
Journal of Organic Chemistry
(2002)
43
4712
(doi: 10.1021/jo00419a007)
NITROGEN ANALOGS OF 1,6-METHANO[12]ANNULENE - EFFECT ON VALENCE TAUTOMERISM OF LOCUS OF AZA SUBSTITUTION
The Journal of Organic Chemistry
(2002)
40
902
(doi: 10.1021/jo00895a020)
Thermal isomerization of homoazocines
Journal of the American Chemical Society
(2002)
100
2909
(doi: 10.1021/ja00477a066)
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