In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
Total synthesis of chloptosin: A dimeric cyclohexapeptide
AJ Oelke, F Antonietti, L Bertone, PB Cranwell, DJ France, RJM Goss, T Hofmann, S Knauer, SJ Moss, PC Skelton, RM Turner, G Wuitschik, SV Ley - Chemistry (
2011)
17, 4183
(DOI:
10.1002/chem.201003216)
Oxidation Reactions in Segmented and Continuous Flow Chemical Processing Using an N-(tert-Butyl)phenylsulfinimidoyl Chloride Monolith
H Lange, MJ Capener, AX Jones, CJ Smith, N Nikbin, IR Baxendale, SV Ley - Synlett (
2011)
2011, 869
(DOI:
10.1055/s-0030-1259923)
Lesser-Known Enabling Technologies for Organic Synthesis
M O'Brien, R Denton, SV Ley - Synthesis (
2011)
2011, 1157
(DOI:
10.1055/s-0030-1259979)
Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent.
CJ Smith, CD Smith, N Nikbin, SV Ley, IR Baxendale - Organic and Biomolecular Chemistry (
2011)
9, 1927
(DOI:
10.1039/c0ob00813c)
A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles.
CJ Smith, N Nikbin, SV Ley, H Lange, IR Baxendale - Organic and Biomolecular Chemistry (
2011)
9, 1938
(DOI:
10.1039/c0ob00815j)
Diastereoselective chain-elongation reactions using microreactors for applications in complex molecule assembly
CF Carter, H Lange, D Sakai, IR Baxendale, SV Ley - Chemistry (
2011)
17, 3398
(DOI:
10.1002/chem.201003148)
Allosteric Modulation of Hormone Release from Thyroxine and Corticosteroid-binding Globulins
XQ Qi, F Loiseau, WL Chan, YH Yan, ZQ Wei, LG Milroy, RM Myers, SV Ley, RJ Read, RW Carrell, AW Zhou - J Biol Chem (
2011)
286, 16163
(DOI:
10.1074/jbc.M110.171082)
The continuous-flow synthesis of carboxylic acids using CO2 in a tube-in-tube gas permeable membrane reactor.
A Polyzos, M O'Brien, TP Petersen, IR Baxendale, SV Ley - Angew Chem Int Ed Engl (
2011)
50, 1190
(DOI:
10.1002/anie.201006618)
Safe and reliable synthesis of diazoketones and quinoxalines in a continuous flow reactor
LJ Martin, AL Marzinzik, SV Ley, IR Baxendale - Organic Letters (
2011)
13, 320
(DOI:
10.1021/ol1027927)
Total syntheses of subereamollines A and B.
JW Shearman, RM Myers, JD Brenton, SV Ley - Organic and Biomolecular Chemistry (
2011)
9, 62
(DOI:
10.1039/c0ob00636j)
