In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
The flow synthesis of heterocycles for natural product and medicinal chemistry applications.
M Baumann, IR Baxendale, SV Ley - Mol Divers (
2010)
15, 613
(DOI:
10.1007/s11030-010-9282-1)
Enzymatic Oxidative Cyclisation Reactions Leading to Dibenzoazocanes
F Tozzi, SV Ley, MO Kitching, IR Baxendale - Synlett (
2010), 1919
(DOI:
10.1055/s-0030-1258486)
A Palladium Wall Coated Microcapillary Reactor for Use in Continuous Flow Transfer Hydrogenation
CH Hornung, B Hallmark, MR Mackley, IR Baxendale, SV Ley - Advanced Synthesis and Catalysis (
2010)
352, 1736
(DOI:
10.1002/adsc.201000139)
Multiple microcapillary reactor for organic synthesis
CH Hornung, B Hallmark, M Baumann, IR Baxendale, SV Ley, P Hester, P Clayton, MR Mackley - Industrial and Engineering Chemistry Research (
2010)
49, 4576
(DOI:
10.1021/ie901674h)
The application of flow microreactors to the preparation of a family of casein kinase I inhibitors
F Venturoni, N Nikbin, SV Ley, IR Baxendale - Organic and Biomolecular Chemistry (
2010)
8, 1798
(DOI:
10.1039/b925327k)
A flow-based synthesis of Imatinib: the API of Gleevec
MD Hopkin, IR Baxendale, SV Ley - Chemical Communications (
2010)
46, 2450
(DOI:
10.1039/c001550d)
The continuous flow synthesis of butane-2,3-diacetal protected building blocks using microreactors
CF Carter, IR Baxendale, JBJ Pavey, SV Ley - Organic and Biomolecular Chemistry (
2010)
8, 1588
(DOI:
10.1039/b924309g)
Flow Ozonolysis Using a Semipermeable Teflon AF-2400 Membrane To Effect Gas-Liquid Contact
M O'Brien, IR Baxendale, SV Ley - Organic Letters (
2010)
12, 1596
(DOI:
10.1021/ol100322t)
Targeting transthyretin - X-ray crystallography and rational drug design
S Kolstoe, AJ Morrison, AJA Cobb, A Coyne, R Gill, MD Smith, SV Ley, SP Wood, MB Pepys - AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2010) 17, 102
Novel palindromic ligands cementing the native quaternary structure of transthyretin
PP Mangione, V Bellotti, S Deroo, GW Taylor, MG McCammon, CV Robinson, GA Tennent, MD Smith, AJ Morrison, AJA Cobb, A Coyne, SV Ley, SW Wood, MB Pepys - AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2010) 17, 49
