In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
Microwave and flow syntheses of Pseudomonas quinolone signal (PQS) and analogues.
JT Hodgkinson, WRJD Galloway, S Saraf, IR Baxendale, SV Ley, M Ladlow, M Welch, DR Spring - Organic and Biomolecular Chemistry (
2011)
9, 57
(DOI:
10.1039/c0ob00652a)
Total synthesis of iso- and bongkrekic acids: natural antibiotics displaying potent antiapoptotic properties.
A Français, A Leyva-Pérez, G Etxebarria-Jardi, J Peña, SV Ley - Chemistry (
2011)
17, 329
(DOI:
10.1002/chem.201002380)
The lab of the future: The importance of remote monitoring and control
MD Hopkin, IR Baxendale, SV Ley - Chimica Oggi (2011) 29, 28
Hydrogenation in flow: Homogeneous and heterogeneous catalysis using Teflon AF-2400 to effect gas-liquid contact at elevated pressure
M O'Brien, N Taylor, A Polyzos, IR Baxendale, SV Ley - Chemical Science (
2011)
2, 1250
(DOI:
10.1039/c1sc00055a)
A breakthrough method for the accurate addition of reagents in multi-step segmented flow processing
H Lange, CF Carter, MD Hopkin, A Burke, JG Goode, IR Baxendale, SV Ley - Chemical Science (
2011)
2, 765
(DOI:
10.1039/c0sc00603c)
Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor.
L Malet-Sanz, J Madrzak, SV Ley, IR Baxendale - Organic and Biomolecular Chemistry (
2010)
8, 5324
(DOI:
10.1039/c0ob00450b)
Trapping of palindromic ligands within native transthyretin prevents amyloid formation
SE Kolstoe, PP Mangione, V Bellotti, GW Taylor, GA Tennent, S Deroo, AJ Morrison, AJA Cobb, A Coyne, MG McCammon, TD Warner, J Mitchell, R Gill, MD Smith, SV Ley, CV Robinson, SP Wood, MB Pepys - Proceedings of the National Academy of Sciences of the United States of America (
2010)
107, 20483
(DOI:
10.1073/pnas.1008255107)
A continuous flow process using a sequence of microreactors with in-line IR analysis for the preparation of N,N-diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide as a potent and highly selective δ-opioid receptor agonist.
ZZ Qian, IR Baxendale, SV Ley - Chemistry (
2010)
16, 12342
(DOI:
10.1002/chem.201002147)
Total syntheses of the bromotyrosine-derived natural products ianthelline, 5-bromoverongamine and JBIR-44
JW Shearman, RM Myers, TM Beale, JD Brenton, SV Ley - Tetrahedron Letters (
2010)
51, 4812
(DOI:
10.1016/j.tetlet.2010.07.016)
Antivascular and anticancer activity of dihalogenated A-ring analogues of combretastatin A-4
TM Beale, RM Myers, JW Shearman, DS Charnock-Jones, JD Brenton, FV Gergely, SV Ley - MedChemComm (
2010)
1, 202
(DOI:
10.1039/c0md00095g)
