In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
Syngas-Mediated C-C Bond Formation in Flow: Selective Rhodium-Catalysed Hydroformylation of Styrenes
S Kasinathan, SL Bourne, P Tolstoy, P Koos, M O'Brien, RW Bates, IR Baxendale, SV Ley - Synlett (
2011)
2011, 2648
(DOI:
10.1055/s-0031-1289292)
Teflon AF-2400 mediated gas-liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentration
P Koos, U Gross, A Polyzos, M O'Brien, I Baxendale, SV Ley - Organic and Biomolecular Chemistry (
2011)
9, 6903
(DOI:
10.1039/c1ob06017a)
Piperazic acid-containing natural products: Isolation, biological relevance and total synthesis
AJ Oelke, DJ France, T Hofmann, G Wuitschik, SV Ley - Nat Prod Rep (
2011)
28, 1445
(DOI:
10.1039/c1np00041a)
Synthesis of a Drug-Like Focused Library of Trisubstituted Pyrrolidines Using Integrated Flow Chemistry and Batch Methods
M Baumann, IR Baxendale, C Kuratli, SV Ley, RE Martin, J Schneider - ACS Comb Sci (
2011)
13, 405
(DOI:
10.1021/co2000357)
The clerodane ring system: investigating the viability of a direct Diels-Alder approach
AT Merritt, RH Pouwer, DJ Williams, CM Williams, SV Ley - Organic and Biomolecular Chemistry (
2011)
9, 4745
(DOI:
10.1039/c1ob05422h)
A new enabling technology for convenient laboratory scale continuous flow processing at low temperatures
DL Browne, M Baumann, BH Harji, IR Baxendale, SV Ley - Organic Letters (
2011)
13, 3312
(DOI:
10.1021/ol2010006)
An Integrated Flow and Batch-Based Approach for the Synthesis of O-Methyl Siphonazole
M Baumann, IR Baxendale, M Brasholz, JJ Hayward, SV Ley, N Nikbin - Synlett (
2011)
2011, 1375
(DOI:
10.1055/s-0030-1260573)
Retinoic acid receptor signaling regulates choroid fissure closure through independent mechanisms in the ventral optic cup and periocular mesenchyme
G Lupo, G Gestri, M O'Brien, RM Denton, RAS Chandraratna, SV Ley, WA Harris, SW Wilson - Proceedings of the National Academy of Sciences of the United States of America (
2011)
108, 8698
(DOI:
10.1073/pnas.1103802108)
Continuous Flow Processing of Slurries: Evaluation of an Agitated Cell Reactor
DL Browne, BJ Deadman, R Ashe, IR Baxendale, SV Ley - Organic Process Research and Development (
2011)
15, 693
(DOI:
10.1021/op2000223)
An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticals.
M Baumann, IR Baxendale, SV Ley, N Nikbin - Beilstein J Org Chem (
2011)
7, 442
(DOI:
10.3762/bjoc.7.57)
