In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
Lesser-Known Enabling Technologies for Organic Synthesis
M O'Brien, R Denton, SV Ley - Synthesis (
2011), 1157
(DOI:
10.1055/s-0030-1259979)
Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent.
CJ Smith, CD Smith, N Nikbin, SV Ley, IR Baxendale - Organic and Biomolecular Chemistry (
2011)
9, 1927
(DOI:
10.1039/c0ob00813c)
A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles.
CJ Smith, N Nikbin, SV Ley, H Lange, IR Baxendale - Organic and Biomolecular Chemistry (
2011)
9, 1938
(DOI:
10.1039/c0ob00815j)
Diastereoselective chain-elongation reactions using microreactors for applications in complex molecule assembly
CF Carter, H Lange, D Sakai, IR Baxendale, SV Ley - Chemistry (
2011)
17, 3398
(DOI:
10.1002/chem.201003148)
The continuous-flow synthesis of carboxylic acids using CO2 in a tube-in-tube gas permeable membrane reactor.
A Polyzos, M O'Brien, TP Petersen, IR Baxendale, SV Ley - Angew Chem Int Ed Engl (
2011)
50, 1190
(DOI:
10.1002/anie.201006618)
Safe and reliable synthesis of diazoketones and quinoxalines in a continuous flow reactor
LJ Martin, AL Marzinzik, SV Ley, IR Baxendale - Organic Letters (
2011)
13, 320
(DOI:
10.1021/ol1027927)
Total syntheses of subereamollines A and B.
JW Shearman, RM Myers, JD Brenton, SV Ley - Organic and Biomolecular Chemistry (
2011)
9, 62
(DOI:
10.1039/c0ob00636j)
Microwave and flow syntheses of Pseudomonas quinolone signal (PQS) and analogues.
JT Hodgkinson, WRJD Galloway, S Saraf, IR Baxendale, SV Ley, M Ladlow, M Welch, DR Spring - Organic and Biomolecular Chemistry (
2011)
9, 57
(DOI:
10.1039/c0ob00652a)
Total synthesis of iso- and bongkrekic acids: natural antibiotics displaying potent antiapoptotic properties.
A Français, A Leyva-Pérez, G Etxebarria-Jardi, J Peña, SV Ley - Chemistry (
2011)
17, 329
(DOI:
10.1002/chem.201002380)
The lab of the future: The importance of remote monitoring and control
MD Hopkin, IR Baxendale, SV Ley - Chimica Oggi (2011) 29, 28
