Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Professor Steven V Ley CBE FRS FMedSci
– Tetrahedron
(2018)
74,
3086
(doi: 10.1016/j.tet.2018.05.047)
Engineering chemistry for the future of organic synthesis Preface
– Tetrahedron
(2018)
74,
3085
(doi: 10.1016/j.tet.2018.05.046)
Continuous Flow Hydration of Pyrazine-2-carbonitrile in a Manganese Dioxide Column Reactor
– Organic Syntheses
(2018)
94,
34
(doi: 10.1002/0471264229.os094.03)
Mimicking the surface and prebiotic chemistry of early Earth using flow chemistry
– Nature Communications
(2018)
9,
1821
(doi: 10.1038/s41467-018-04147-2)
Editorial: Harmonische Zusammenarbeit von Mensch und Maschine in der chemischen Synthese
– Angewandte Chemie
(2018)
130,
5278
(doi: 10.1002/ange.201802383)
The Engineering of Chemical Synthesis: Humans and Machines Working in Harmony
– Angewandte Chemie - International Edition
(2018)
57,
5182
(doi: 10.1002/anie.201802383)
Diastereoselective synthesis of functionalized indolines using in situ generated allyl boronic species.
– Synlett
(2018)
29,
825
(doi: 10.1055/s-0036-1589164)
Rapid, selective and stable HaloTag-LbADH immobilization directly from crude cell extract for the continuous biocatalytic production of chiral alcohols and epoxides
– Reaction Chemistry & Engineering
(2018)
3,
8
(doi: 10.1039/c7re00173h)
Engineering Chemistry to Enable Bioactive Small Molecule Discovery
(2018)
10,
184
Real-time spectroscopic analysis enabling quantitative and safe consumption of fluoroform during nucleophilic trifluoromethylation in flow.
– ACS Sustainable Chemistry and Engineering
(2018)
6,
1489
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