In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
On being green: Can flow chemistry help?
SV Ley - Chemical Record (2012) 12, 378
Increased endothelial cell selectivity of triazole-bridged dihalogenated A-ring analogues of combretastatin A-1
TM Beale, PJ Bond, JD Brenton, DS Charnock-Jones, SV Ley, RM Myers - Bioorganic and Medicinal Chemistry (2012) 20, 1749
Erratum to: The coming age of azarcirachtins and related tetranortriterpinoids 5, 82
EH Hans, DF Hein, H Schumatterer, SV Ley, ED Morgan, W Kraus - Journal of Biopesticides (2012) 5, 170
A total synthesis of the ammonium ionophore, (-)-enniatin B
DX Hu, M Bielitza, P Koos, SV Ley - Tetrahedron Letters (2012) 53, 4077
Piecing together the puzzle: understanding a mild, metal free reduction method for the large scale synthesis of hydrazines
DL Browne, IR Baxendale, SV Ley - Tetrahedron (
2011)
67, 10296
(DOI:
10.1016/j.tet.2011.09.146)
The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors.
KA Roper, H Lange, A Polyzos, MB Berry, IR Baxendale, SV Ley - Beilstein J Org Chem (
2011)
7, 1648
(DOI:
10.3762/bjoc.7.194)
The Continuous-Flow Synthesis of Styrenes Using Ethylene in a Palladium-Catalysed Heck Cross-Coupling Reaction
SL Bourne, P Koos, M O'Brien, B Martin, B Schenkel, IR Baxendale, SV Ley - Synlett (
2011), 2643
(DOI:
10.1055/s-0031-1289291)
Syngas-Mediated C-C Bond Formation in Flow: Selective Rhodium-Catalysed Hydroformylation of Styrenes
S Kasinathan, SL Bourne, P Tolstoy, P Koos, M O'Brien, RW Bates, IR Baxendale, SV Ley - Synlett (
2011), 2648
(DOI:
10.1055/s-0031-1289292)
Teflon AF-2400 mediated gas-liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentration
P Koos, U Gross, A Polyzos, M O'Brien, I Baxendale, SV Ley - Organic and Biomolecular Chemistry (
2011)
9, 6903
(DOI:
10.1039/c1ob06017a)
Piperazic acid-containing natural products: Isolation, biological relevance and total synthesis
AJ Oelke, DJ France, T Hofmann, G Wuitschik, SV Ley - Nat Prod Rep (
2011)
28, 1445
(DOI:
10.1039/c1np00041a)
