In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
Synthesis of a ceramide sphingolipid as a potential sex pheromone of the hair crab Erimacrus isenbeckii using butane-2,3-diacetal desymmetrised glycolic acid building blocks
DJ Dixon, SV Ley, S Lohmann, TD Sheppard - Synlett (
2005), 481
(DOI:
10.1055/s-2005-862361)
Total synthesis of the Fusarium toxin equisetin
LT Burke, DJ Dixon, SV Ley, F Rodriguez - Organic and Biomolecular Chemistry (
2005)
3, 274
(DOI:
10.1039/b411350k)
The total synthesis of the annonaceous acetogenin 10-hydroxyasimicin
GL Nattrass, E Diez, MM McLachlan, DJ Dixon, SV Ley - Angew Chem Int Ed Engl (
2005)
44, 580
(DOI:
10.1002/anie.200462264)
Organocatalysis with proline derivatives: improved catalysts for the asymmetric Mannich, nitro-Michael and aldol reactions
AJA Cobb, DM Shaw, DA Longbottom, JB Gold, SV Ley - Organic and Biomolecular Chemistry (
2005)
3, 84
(DOI:
10.1039/b414742a)
Integrated Microwave Assisted Synthesis and Solid-Supported Reagents
IR Baxendale, A-L Lee, SV Ley - (2005), 133
Erratum: Copper- and palladium-containing Perovskites: Catalysts for the Ullmann and Sonogashira reactions (Synlett (2005) (1291))
S Lohmann, SP Andrews, BJ Burke, MD Smith, JP Attfield, H Tanaka, K Kaneko, SV Ley - Synlett (2005), 1490
Studies on the generation of enolate anions from butane-2,3-diacetal protected glycolic acid derivatives and subsequent highly diastereoselective coupling reactions with aldehydes and acid chlorides.
SV Ley, DJ Dixon, RT Guy, MA Palomero, A Polara, F Rodriguez, TD Sheppard - Organic and Biomolecular Chemistry (
2004)
2, 3618
(DOI:
10.1039/b412790k)
Preparation of enantiopure butane-2,3-diacetals of glycolic acid and alkylation reactions leading to alpha-hydroxyacid and amide derivatives
SV Ley, E Diez, DJ Dixon, RT Guy, P Michel, GL Nattrass, TD Sheppard - Organic and Biomolecular Chemistry (
2004)
2, 3608
(DOI:
10.1039/b412788a)
A concise total synthesis of (+)-okaramine C.
PR Hewitt, E Cleator, SV Ley - Organic and Biomolecular Chemistry (
2004)
2, 2415
(DOI:
10.1039/B410180D)
Enantioselective organocatalytic cyclopropanation via ammonium ylides.
CD Papageorgiou, MAC de Dios, SV Ley, MJ Gaunt - Angew Chem Int Ed Engl (
2004)
43, 4641
(DOI:
10.1002/anie.200460234)
