In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
Total synthesis of antascomicin B.
DEA Brittain, CM Griffiths-Jones, MR Linder, MD Smith, C McCusker, JS Barlow, R Akiyama, K Yasuda, SV Ley - Angew Chem Int Ed Engl (
2005)
44, 2732
(DOI:
10.1002/anie.200500174)
Efficient batch and continuous flow Suzuki cross-coupling reactions under mild conditions, catalysed by polyurea-encapsulated palladium (II) acetate and tetra-n-butylammonium salts
CKY Lee, AB Holmes, SV Ley, IF McConvey, B Al-Duri, GA Leeke, RCD Santos, JPK Seville - Chemical Communications (
2005), 2175
(DOI:
10.1039/b418669a)
Organic chemistry in ionic liquids using non-thermal energy-transfer processes
J Habermann, S Ponzi, SV Ley - Mini-Reviews in Organic Chemistry (
2005)
2, 125
(DOI:
10.2174/1570193053544454)
Heterogeneous or homogeneous? A case study involving palladium-containing perovskites in the Suzuki reaction
SP Andrews, AF Stepan, H Tanaka, SV Ley, MD Smith - Advanced Synthesis & Catalysis (
2005)
347, 647
(DOI:
10.1002/adsc.200404331)
Stereoselective synthesis of chiral tetrahydrofurans with potent 5-LO inhibitory activity
GVM Sharma, S Punna, PR Krishna, MS Chorghade, SV Ley - Tetrahedron Asymmetry (
2005)
16, 1125
(DOI:
10.1016/j.tetasy.2005.01.045)
Stereoselective synthesis of (2R,3S,4S,5R)-trans-3,4-dihydroxy-5-(4-fluorophenoxymethyl)-2-(1-N-hydroxyureidyl-3-butyn-4-yl)tetrahydrofuran and (2R,3S,4S,5R)-trans-5-ethynyl-2(4-fluorophenoxymethyl)-3,4-O-isopropylidene tetrahydrofuran from mannose diacetonide
GVM Sharma, S Punna, L Hymavathi, NY Reddy, PR Krishna, MS Chorghade, SV Ley - Tetrahedron Asymmetry (
2005)
16, 1135
(DOI:
10.1016/j.tetasy.2005.01.046)
Stereoselective syntheses of pharmaceutically relevant chiral tetrahydrofurans from (S)- and (R)-glyceraldehyde derivatives
GVM Sharma, S Punna, TR Prasad, PR Krishna, MS Chorghade, SV Ley - Tetrahedron Asymmetry (
2005)
16, 1113
(DOI:
10.1016/j.tetasy.2005.01.044)
Stereoselective synthesis of (2S,7S)-7-(4-phenoxymethyl)2-(1-N-hydroxyureidyl-3-butyn-4-yl)oxepane: a potential anti-asthmatic drug candidate
MK Gurjar, BV Rao, LM Krishna, MS Chorghade, SV Ley - Tetrahedron Asymmetry (
2005)
16, 935
(DOI:
10.1016/j.tetasy.2005.01.024)
Highly diastereoselective desymmetrisation of cyclic meso-anhydrides and derivatisation to mono-protected 1,4-diols
AC Evans, DA Longbottom, M Matsuoka, SV Ley - Synlett (
2005), 646
(DOI:
10.1055/s-2005-862393)
A homo-proline tetrazole as an improved organocatalyst for the asymmetric Michael addition of carbonyl compounds to nitro-olefins
CET Mitchell, AJA Cobb, SV Ley - Synlett (
2005), 611
(DOI:
10.1055/s-2005-862392)
