In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
A phase-switch purification approach for the expedient removal of tagged reagents and scavengers following their application in organic synthesis
J Siu, IR Baxendale, RA Lewthwaite, SV Ley - Organic and Biomolecular Chemistry (
2005)
3, 3140
(DOI:
10.1039/b503778f)
Total synthesis of Spongistatin 1: A synthetic strategy exploiting its latent pseudo-symmetry
M Ball, MJ Gaunt, DF Hook, AS Jessiman, S Kawahara, P Orsini, A Scolaro, AC Talbot, HR Tanner, S Yamanoi, SV Ley - Angew Chem Int Ed Engl (
2005)
44, 5433
(DOI:
10.1002/anie.200502008)
Synthesis of the EF fragment of spongistatin 1
S Kawahara, MJ Gaunt, A Scolaro, S Yamanoi, SV Ley - Synlett (
2005), 2031
(DOI:
10.1055/s-2005-871960)
Development of methods suitable for natural product synthesis: The azadirachtin story
SV Ley - Pure and Applied Chemistry (
2005)
77, 1115
(DOI:
10.1351/pac200577071115)
The use of a continuous flow-reactor employing a mixed hydrogen-liquid flow stream for the efficient reduction of imines to amines
S Saaby, KR Knudsen, M Ladlow, SV Ley - Chemical Communications (
2005), 2909
(DOI:
10.1039/b504854k)
Copper- and palladium-containing perovskites: Catalysts for the Ullmann and Sonogashira reactions (pg 1291, 2005)
S Lohmann, SP Andrews, BJ Burke, MD Smith, JP Attfield, H Tanaka, K Kaneko, SV Ley - SYNLETT (2005), 1490
The rapid preparation of 2-aminosulfonamide-1,3,4-oxadiazoles using polymer-supported reagents and microwave heating
IR Baxendale, SV Ley, M Martinelli - Tetrahedron (
2005)
61, 5323
(DOI:
10.1016/j.tet.2005.03.062)
Copper- and palladium-containing perovskites: Catalysts for the Ullmann and Sonogashira reactions
S Lohmann, SP Andrews, BJ Burke, MD Smith, JP Attfield, H Tanaka, K Kaneko, SV Ley - Synlett (
2005), 1291
(DOI:
10.1055/s-2005-865233)
Formation of 4-aminopyrimidines via the trimerization of nitriles using focused microwave heating
IR Baxendale, SV Ley - Journal of Combinatorial Chemistry (
2005)
7, 483
(DOI:
10.1021/cc049826d)
A highly automated, polymer-assisted strategy for the preparation of 2-alkylthiobenzimidazoles and N,N'-dialkylbenzimidazolin-2-ones.
E Vickerstaffe, BH Warrington, M Ladlow, SV Ley - Journal of Combinatorial Chemistry (
2005)
7, 385
(DOI:
10.1021/cc049832+)
