In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
Erratum: Diastereoselective aldol reactions with butane-2,3-diacetal protected glyceraldehyde derivatives (Organic and Biomolecular Chemistry (2006) 4 (1471-1473)) DOI: 10.1039/b601888b))
KR Knudsen, AF Stepan, P Michel, SV Ley - Organic and Biomolecular Chemistry (2006) 4, 1612
Diastereoselective aldol reactions with butane-2,3-diacetal protected glyceraldehyde derivatives (vol 4, pg 1471, 2006)
KR Knudsen, AF Stepan, P Michel, SV Ley - ORGANIC & BIOMOLECULAR CHEMISTRY (2006) 4, 1612
Michael, Michael-aldol and Michael-Michael reactions of enolate equivalents of butane-2,3-diacetal protected glycolic acid derivatives
SV Ley, DJ Dixon, RT Guy, F Rodriguez, TD Sheppard - Organic and Biomolecular Chemistry (
2005)
3, 4095
(DOI:
10.1039/b512410g)
A versatile organocatalyst for the asymmetric conjugate addition of nitroalkanes to enones.
CET Mitchell, SE Brenner, SV Ley - Chemical Communications (
2005), 5346
(DOI:
10.1039/b511441a)
Synthesis of the alkaloid natural products (+)-plicane and (-)-obliquine, using polymer-supported reagents and scavengers
IR Baxendale, SV Ley - Industrial and Engineering Chemistry Research (
2005)
44, 8588
(DOI:
10.1021/ie048822i)
Total synthesis of two novel subpicomolar sarco/endoplasmatic reticulum Ca2+-ATPase inhibitors designed by an analysis of the binding site of thapsigargin
H Sohoel, T Lijefors, SV Ley, SF Oliver, A Antonello, MD Smith, CE Olsen, JT Isaacs, SB Christensen - J Med Chem (
2005)
48, 7005
(DOI:
10.1021/jm058036v)
Evolution or Revolution: The Challenge to the Modern Medicinal Chemist
IR Baxendale, SV Ley - (2005), 1
Synthesis of alkaloid natural products using solid-supported reagents and scavengers
IR Baxendale, SV Ley - Current Organic Chemistry (
2005)
9, 1521
(DOI:
10.2174/138527205774370513)
Non-metal-catalysed intramolecular alkyne cyclotrimerization reactions promoted by focussed microwave heating in batch and flow modes.
S Saaby, IR Baxendale, SV Ley - Organic and Biomolecular Chemistry (
2005)
3, 3365
(DOI:
10.1039/b509540a)
A highly selective, organocatalytic route to chiral dihydro-1,2-oxazines
S Kumarn, DM Shaw, DA Longbottom, SV Ley - Organic Letters (
2005)
7, 4189
(DOI:
10.1021/ol051577u)
