In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
Chemical variation of natural product-like scaffolds: design and synthesis of spiroketal derivatives
G Zinzalla, LG Milroy, SV Ley - Organic and Biomolecular Chemistry (
2006)
4, 1977
(DOI:
10.1039/b603015g)
An efficient, asymmetric organocatalyst-mediated conjugate addition of nitroalkanes to unsaturated cyclic and acyclic ketones.
CET Mitchell, SE Brenner, J Garcia-Fortanet, SV Ley - Organic and Biomolecular Chemistry (
2006)
4, 2039
(DOI:
10.1039/b601877g)
A highly enantioselective total synthesis of (+)- goniodiol
EW Tate, DJ Dixon, SV Ley - Organic and Biomolecular Chemistry (
2006)
4, 1698
(DOI:
10.1039/b602805e)
Targeting C-reactive protein for the treatment of cardiovascular disease
MB Pepys, GM Hirschfield, GA Tennent, JR Gallimore, MC Kahan, V Bellotti, PN Hawkins, RM Myers, MD Smith, A Polara, AJA Cobb, SV Ley, JA Aquilina, CV Robinson, I Sharif, GA Gray, CA Sabin, MC Jenvey, SE Kolstoe, D Thompson, SP Wood - Nature (
2006)
440, 1217
(DOI:
10.1038/nature04672)
Diastereoselective aldol reactions with butane-2,3-diacetal protected glyceraldehyde derivatives
KR Knudsen, AF Stepan, P Michel, SV Ley - Organic and Biomolecular Chemistry (
2006)
4, 1471
(DOI:
10.1039/b601888b)
Practical synthesis of (S)-pyrrolidin-2-yl-1H-tetrazole, incorporating efficient protecting group removal by flow-reactor hydrogenolysis
V Franckevicius, KR Knudsen, M Ladlow, DA Longbottom, SV Ley - Synlett (
2006)
2006, 889
(DOI:
10.1055/s-2006.939036)
Double conjugate addition of dithiols to propargylic carbonyl systems to generate protected 1,3-dicarbonyl compounds
HF Sneddon, A van den Heuvel, AKH Hirsch, RA Booth, DM Shaw, MJ Gaunt, SV Ley - J Org Chem (
2006)
71, 2715
(DOI:
10.1021/jo052514s)
Preparation of the neolignan natural product grossamide by a continuous-flow process
IR Baxendale, CM Griffiths-Jones, SV Ley, GK Tranmer - Synlett (
2006), 427
(DOI:
10.1055/S-2006-926244)
Asymmetric organocatalytic conjugate addition of malonates to enones using a proline tetrazole catalyst.
KR Knudsen, CET Mitchell, SV Ley - Chemical Communications (
2006), 66
(DOI:
10.1039/b514636d)
The Use of Polymer Supported Reagents and Scavengers in the Synthesis of Natural Products
IR Baxendale, RM Myers, SV Ley - (2006), 6
