In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols.
IR Baxendale, SV Ley, CD Smith, GK Tranmer - Chemical Communications (
2006), 4835
(DOI:
10.1039/b612197g)
Fully automated continuous flow synthesis of 4,5-disubstituted oxazoles.
M Baumann, IR Baxendale, SV Ley, CD Smith, GK Tranmer - Organic Letters (
2006)
8, 5231
(DOI:
10.1021/ol061975c)
Stereocontrolled total synthesis of bengazole a: a marine bisoxazole natural product displaying potent antifungal properties.
JA Bull, EP Balskus, RAJ Horan, M Langner, SV Ley - Angew Chem Int Ed Engl (
2006)
45, 6714
(DOI:
10.1002/anie.200602050)
An enantioselective organocatalytic route to chiral 3,6-dihydropyridazines from aldehydes
AJ Oelke, S Kumarn, DA Longbottom, SV Ley - Synlett (
2006)
2006, 2548
(DOI:
10.1055/s-2006-951486)
8,9,10,10a-tetrahydro-6H-tetrazolo[1,5-a]pyrrolo[2,1-c]pyrazines: New heterocyclic frameworks generated by an Ugi-type multicomponent reaction
V Franckevicius, DA Longbottom, RM Turner, SV Ley - Synthesis (
2006)
2006, 3215
(DOI:
10.1055/s-2006-950219)
Enantioselective catalytic intramolecular cyclopropanation using modified cinchona alkaloid organocatalysts.
CCC Johansson, N Bremeyer, SV Ley, DR Owen, SC Smith, MJ Gaunt - Angew Chem Int Ed Engl (
2006)
45, 6024
(DOI:
10.1002/anie.200602129)
Hydrogenation of aromatic ketones, aldehydes, and epoxides with hydrogen and Pd(0)EnCat™ 30NP
SV Ley, AJP Stewart-Liddon, D Pears, RH Perni, K Treacher - Beilstein J Org Chem (
2006)
2, 15
(DOI:
10.1186/1860-5397-2-15)
A highly selective, organocatalytic route to chiral 1,2-oxazines from ketones.
S Kumarn, DM Shaw, SV Ley - Chemical Communications (
2006), 3211
(DOI:
10.1039/b606338a)
A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: A new paradigm for molecular assembly
IR Baxendale, J Deeley, CM Griffiths-Jones, SV Ley, S Saaby, GK Tranmer - Chemical Communications (
2006), 2566
(DOI:
10.1039/b600382f)
Microwave-assisted Suzuki coupling reactions with an encapsulated palladium catalyst for batch and continuous-flow transformations.
IR Baxendale, CM Griffiths-Jones, SV Ley, GK Tranmer - Chemistry (
2006)
12, 4407
(DOI:
10.1002/chem.200501400)
