In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
Total synthesis of five thapsigargins: Guaianolide natural products exhibiting sub-nanomolar SERCA inhibition
SP Andrews, M Ball, F Wierschem, E Cleator, S Oliver, K Hogenauer, O Simic, A Antonello, U Hunger, MD Smith, SV Ley - Chemistry (
2007)
13, 5688
(DOI:
10.1002/chem.200700302)
Synthesis of azadirachtin: a long but successful journey.
GE Veitch, E Beckmann, BJ Burke, A Boyer, SL Maslen, SV Ley - Angew Chem Int Ed Engl (
2007)
46, 7629
(DOI:
10.1002/anie.200703027)
Solid supported reagents in multi-step flow synthesis.
IR Baxendale, SV Ley - Ernst Schering Foundation symposium proceedings (2007) 3, 151
(S)- and (R)-5-Pyrrolidin-2-yl-1H-tetrazoles: Enantiomeric organocatalysts of broad utility in organic synthesis
DA Longbottom, V Franckevicius, SV Ley - CHIMIA International Journal for Chemistry (
2007)
61, 247
(DOI:
10.2533/chimia.2007.247)
New avenues to efficient chemical synthesis
IR Baxendale, SV Ley - (2007), 151
Natural Products as an Inspiration for the Discovery of New High Throughput Chemical Synthesis Tools In Drug Discovery & Development
IR Baxendale, RM Myers, DA Longbottom, SV Ley - (2007), 51
Chemical variation of natural-product-like scaffolds: design, synthesis, and biological activity of fused bicyclic acetal derivatives.
LG Milroy, G Zinzalla, G Prencipe, P Michel, SV Ley, M Gunaratnam, M Beltran, S Neidle - Angew Chem Int Ed Engl (
2007)
46, 2493
(DOI:
10.1002/anie.200604688)
A relay route for the synthesis of azadirachtin
GE Veitch, E Beckmann, BJ Burke, A Boyer, C Ayats, SV Ley - Angew Chem Int Ed Engl (
2007)
46, 7633
(DOI:
10.1002/anie.200703028)
A flow process for the multistep synthesis of the alkaloid natural product oxomaritidine: A new paradigm for molecular assembly
IR Baxendale, J Deeley, CM Griffiths-Jones, SV Ley, S Saaby, GK Tranmer - Chemtracts (2007) 20, 462
A new asymmetric organocatalytic nitrocyclopropanation reaction
HM Hansen, DA Longbottom, SV Ley - Chemical Communications (
2006), 4838
(DOI:
10.1039/b612436b)
