In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
The preparation and alkylation of a butanedione-derived chiral glycine equivalent and its use for the synthesis of α-amino acids and α,α-disubstituted amino acids
CI Harding, DJ Dixon, SV Ley - Tetrahedron (
2004)
60, 7679
(DOI:
10.1016/j.tet.2004.06.063)
5-Pyrrolidin-2-yltetrazole as an asymmetric organocatalyst for the addition of ketones to nitro-olefins
AJA Cobb, DA Longbottom, DM Shaw, SV Ley - Chemical Communications (
2004)
10, 1808
(DOI:
10.1039/b409646k)
Synthesis of the thapsigargins
SV Ley, A Antonello, EP Balskus, DT Booth, SB Christensen, E Cleator, H Gold, K Hogenauer, U Hunger, RM Myers, SF Oliver, O Simic, MD Smith, H Sohoel, AJA Woolford - Proceedings of the National Academy of Sciences of the United States of America (
2004)
101, 12073
(DOI:
10.1073/pnas.0403300101)
Multi-step application of immobilized reagents and scavengers: A total synthesis of epothilone C
RI Storer, T Takemoto, PS Jackson, DS Brown, IR Baxendale, SV Ley - Chemistry (
2004)
10, 2529
(DOI:
10.1002/chem.200305669)
An intramolecular organocatalytic cyclopropanation reaction
N Bremeyer, SC Smith, SV Ley, MJ Gaunt - Angew Chem Int Ed Engl (
2004)
43, 2681
(DOI:
10.1002/anie.200454007)
Fully automated polymer-assisted synthesis of 1,5-biaryl pyrazoles.
E Vickerstaffe, BH Warrington, M Ladlow, SV Ley - Journal of Combinatorial Chemistry (
2004)
6, 332
(DOI:
10.1021/cc049977g)
Development of an indole safety-catch linker using analytical constructs.
JJ Scicinski, MS Congreve, SV Ley - Journal of Combinatorial Chemistry (
2004)
6, 375
(DOI:
10.1021/cc0499791)
Anomeric oxygen to carbon rearrangements of alkynyl tributylstannane derivatives of furanyl (γ)- and pyranyl (δ)-lactols
MF Buffet, DJ Dixon, SV Ley, DJ Reynolds, RI Storer - Organic and Biomolecular Chemistry (
2004)
2, 1145
(DOI:
10.1039/b316858a)
Grignard additions to 2-uloses: Synthesis of stereochemically pure tertiary alcohols
E Cleator, CF McCusker, F Steltzer, SV Ley - Tetrahedron Letters (
2004)
45, 3077
(DOI:
10.1016/j.tetlet.2004.02.106)
Catalytic polymer-supported potassium thiophenolate in methanol as a method for the removal of ester, amide, and thioacetate protecting groups
RN MacCoss, DJ Henry, CT Brain, SV Ley - Synlett (
2004), 675
(DOI:
10.1055/s-2004-817786)
