Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Back pressure regulation of slurry-forming reactions in continuous flow

BJ Deadman, DL Browne, IR Baxendale, SV Ley

Chemical Engineering and Technology

(2015)

259

(doi: 10.1002/ceat.201400445)

Chemistry in a changing world

SV Ley, RM Myers, DE Fitzpatrick

Actualite Chimique

(2015)

Design, Synthesis, and Evaluation of Tetrasubstituted Pyridines as Potent 5‑HT2C Receptor Agonists

G Rouquet, DE Moore, M Spain, DM Allwood, C Battilocchio, DC Blakemore, PV Fish, S Jenkinson, AS Jessiman, SV Ley, G McMurray, RI Storer

ACS Med Chem Lett

(2015)

329

(doi: 10.1021/ml500507v)

Flow Chemistry: Intelligent Processing of Gas-Liquid Transformations Using a Tube-in-Tube Reactor

M Brzozowski, M O'Brien, SV Ley, A Polyzos

Accounts of Chemical Research

(2015)

349

(doi: 10.1021/ar500359m)

Boehmeriasin A as new lead compound for the inhibition of topoisomerases and SIRT2

MS Christodoulou, F Calogero, M Baumann, AN García-Argáez, S Pieraccini, M Sironi, F Dapiaggi, R Bucci, G Broggini, S Gazzola, S Liekens, A Silvani, M Lahtela-Kakkonen, N Martinet, A Nonell-Canals, E Santamaría-Navarro, IR Baxendale, L Dalla Via, D Passarella

Eur J Med Chem

(2015)

766

(doi: 10.1016/j.ejmech.2015.01.038)