In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
A sequential enantioselective, organocatalytic route to chiral 1,2-oxazines and chiral pyridazines
S Kumarn, AJ Oelke, DM Shaw, DA Longbottom, SV Ley - Organic and Biomolecular Chemistry (
2007)
5, 2678
(DOI:
10.1039/b708646f)
Chiral glycolate equivalents for the asymmetric synthesis of alpha-hydroxycarbonyl compounds
SV Ley, TD Sheppard, RM Myers, MS Chorghade - Bulletin of the Chemical Society of Japan (
2007)
80, 1451
(DOI:
10.1246/bcsj.80.1451)
A fascination with 1,2-diacetals
SV Ley, A Polara - J Org Chem (
2007)
72, 5943
(DOI:
10.1021/jo0703451)
Pharmaceutical strategy and innovation: An academics perspective
IR Baxendale, JJ Hayward, SV Ley, GK Tranmer - ChemMedChem (
2007)
2, 768
(DOI:
10.1002/cmdc.200700008)
Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor
CD Smith, IR Baxendale, GK Tranmer, M Baumann, SC Smith, RA Lewthwaitee, SV Ley - Organic and Biomolecular Chemistry (
2007)
5, 1562
(DOI:
10.1039/b703033a)
[3+27] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor
CD Smith, IR Baxendale, S Lanners, JJ Hayward, SC Smith, SV Ley - Organic and Biomolecular Chemistry (
2007)
5, 1559
(DOI:
10.1039/b702995k)
Chromatography-free Suzuki reactions using a polymer-assisted solution-phase (PASP) approach
E Vickerstaffe, AL Villard, M Ladlow, SV Ley - Synlett (
2007), 1251
(DOI:
10.1055/s-2007-977457)
Design and total synthesis of unnatural analogues of the sub-nanomolar SERCA inhibitor thapsigargin
SP Andrews, MM Tait, M Ball, SV Ley - Organic and Biomolecular Chemistry (
2007)
5, 1427
(DOI:
10.1039/b702481a)
Fully automated flow-through synthesis of secondary sulfonamides in a binary reactor system
CM Griffiths-Jones, MD Hopkin, D Jonsson, SV Ley, DJ Tapolczay, E Vickerstaffe, M Ladlow - Journal of Combinatorial Chemistry (
2007)
9, 422
(DOI:
10.1021/cc060152b)
Continuous flow ligand-free Heck reactions using monolithic Pd [0] nanoparticles
N Nikbin, M Ladlow, SV Ley - Organic Process Research and Development (
2007)
11, 458
(DOI:
10.1021/op7000436)
