In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
Magnesium Nitride as a Convenient Source of Ammonia: Preparation of Pyrroles
GE Veitch, KL Bridgwood, K Rands-Trevor, SV Ley - Synlett (
2008)
2008, 2597
(DOI:
10.1055/s-0028-1083504)
Enantiopure 2-Substituted Glyceraidehyde Derivatives by Aza-Claisen Rearrangement or C-Alkylation of Enamines
KL Bridgwood, CC Tzschucke, M O'Brien, S Wittrock, JM Goodman, JE Davies, AWJ Logan, MRM Huttl, SV Ley - Organic Letters (
2008)
10, {4537-4540}
(DOI:
10.1021/ol8018242)
The use of diethylaminosulfur trifluoride (DAST) for fluorination in a continuous-flow microreactor
M Baumann, IR Baxendale, SV Ley - Synlett (
2008)
2008, 2111
(DOI:
10.1055/s-2008-1078026)
Magnesium nitride as a convenient source of ammonia: Preparation of primary amides
GE Veitch, KL Bridgwood, SV Ley - Organic Letters (
2008)
10, 3623
(DOI:
10.1021/ol801398z)
Magnesium nitride as a convenient source of ammonia: Preparation of dihydropyridines
KL Bridgwood, GE Veitch, SV Ley - Organic Letters (
2008)
10, 3627
(DOI:
10.1021/ol801399w)
New focused microwave approach to the synthesis of amino-substituted pyrroloisoquinolines and pyrroloquinolines via a sequential multi-component coupling process
MD Hopkin, IR Baxendale, SV Ley - Synthesis (
2008)
2008, 1688
(DOI:
10.1055/s-2008-1067048)
FeCl(3)-catalysed cleavage of 1,2-butanediacetal protected diols
CC Tzschucke, N Pradidphol, A Dieguez-Vazquez, B Kongkathip, N Kongkathip, SV Ley - Synlett (
2008)
2008, 1293
(DOI:
10.1055/s-2008-1072752)
A new synthesis of (-)-epipyriculol: a phytotoxic metabolite
A Leyva, FE Blum, SV Ley - Tetrahedron (
2008)
64, 4711
(DOI:
10.1016/j.tet.2008.01.115)
Azide monoliths as convenient flow reactors for efficient Curtius rearrangement reactions
M Baumann, IR Baxendale, SV Ley, N Nikbin, CD Smith - Organic and Biomolecular Chemistry (
2008)
6, 1587
(DOI:
10.1039/b801634h)
A modular flow reactor for performing Curtius rearrangements as a continuous flow process
M Baumann, IR Baxendale, SV Ley, N Nikbin, CD Smith, JP Tierney - Organic and Biomolecular Chemistry (
2008)
6, 1577
(DOI:
10.1039/b801631n)
