In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the CRUK PhD Training Programme in Medicinal Chemistry.
For more detailed research information, group members and our publication list please see the group website
16th International Isotope Society (UK group) symposium - Synthesis and applications of labelled compounds 2007
G Aberg, FI Aigbirhio, E Alexakis, N Al-Maharik, M Almi, Y Ambacher, S Andersson, A Athlan, G Badman, SA Baldwin, M Baumann, IR Baxendale, NP Botting, RA Bragg, JA Brown, A Burton, N Bushby, K Cable, G Campbell, R Carr, M Carroll, L Chen, M Christlieb, P Davies, GJ Ellames, W Ellis, C Elmore, T Fryatt, N Geach, JR Harding, S Hartmann, S Harwood, JJ Hayward, PJF Henderson, RB Herbert, JR Heys, S Holzl, MD Hopkin, P Horn, T Ilyas, S Irvine, SD Jackson, J Jin, A Keats, AR Kennedy, WJ Kerr, MO Kitching, C Landreau, S Lanners, R Lawrence, KWM Lawrie, SV Ley, G Little, WJS Lockley, D Maier, C Manning, A Mcneill, DA Middleton, S Montgomery, JJ Morrison, L Mrzuak, J Newman, J Newsome, N Nikbin-Roudsari, GN Nilsson, MF Oldfield, SG Patching, DJ Procter, G Randall, AA Robertson, CS Rummel, D Rustidge, R Sherhod, N Shipley, CD Smith, CJ Smith, DI Smith, C Song, L Tamborini, I Waterhouse, A Watts, JL Werkheiser, G Williams, CL Willis, P Woodward, R Yan, G Young, Q Zhang - J LABELLED COMPD RAD (
2008)
51, 247
(DOI:
10.1002/jlcr.1513)
Functionalised butanediacetal-protected 1,2-diols as suitable partners for Pd-catalysed cross-coupling reactions
A Leyva, FE Blum, PR Hewitt, SV Ley - Tetrahedron (
2008)
64, 2348
(DOI:
10.1016/j.tet.2008.01.010)
Synthesis of natural products from the Indian neem tree Azadirachta indica.
GE Veitch, A Pinto, A Boyer, E Beckmann, JC Anderson, SV Ley - Organic Letters (
2008)
10, 569
(DOI:
10.1021/ol7027898)
Total synthesis studies on macrocyclic pipecolic acid natural products: FK506, the antascomicins and rapamycin.
ML Maddess, MN Tackett, SV Ley - Progress in Drug Research (2008) 66, 13
The Synthesis of Azadirachtin: A Potent Insect Antifeedant
SV Ley, A Abad-Somovilla, JC Anderson, C Ayats, R Banteli, E Beckmann, A Boyer, MG Brasca, A Brice, HB Broughton, BJ Burke, E Cleator, D Craig, AA Denholm, RM Denton, T Durand-Reville, LB Gobbi, M Gobel, BL Gray, RB Grossmann, CE Gutteridge, N Hahn, SL Harding, DC Jennens, L Jennens, PJ Lovell, HJ Lovell, ML de La Puente, HC Kolb, WJ Koot, SL Maslen, CF McCusker, A Mattes, AR Pape, A Pinto, D Santafianos, JS Scott, SC Smith, AQ Somers, CD Spilling, F Stelzer, PL Toogood, RM Turner, GE Veitch, A Wood, C Zumbrunn - Chemistry (
2008)
14, 10683
(DOI:
10.1002/chem.200801103)
The azadirachtin story
GE Veitch, A Boyer, SV Ley - Angew Chem Int Ed Engl (
2008)
47, 9402
(DOI:
10.1002/anie.200802675)
(S)-5-pyrrolidin-2-yl-1H-tetrazole
V Aureggi, V Franckevičius, MO Kitching, SV Ley, DA Longbottom, AJ Oelke, G Sedelmeier - Organic Syntheses (2008) 85, 72
PtCl4-catalyzed domino synthesis of fused bicyclic acetals
A Dieguez-Vazquez, CC Tzschucke, WY Lam, SV Ley - Angew Chem Int Ed Engl (
2008)
47, 209
(DOI:
10.1002/anie.200704595)
Practical organocatalysis with (S)- and (r)-5-pyrrolidin-2-yl-1H-tetrazoles
DA Longbottom, V Franckevicius, S Kumarn, AJ Oelke, V Wascholowski, SV Ley - Aldrichimica Acta (2008) 41, 3
