University Professor
Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation.
Professor Collepardo discusses her research
Publications
Length Scale-Dependent Dynamics in Electrostatic Protein Coacervates
(2026)
(doi: 10.64898/2026.03.27.714715)
Pushing the experimental resolution boundary in chromatin fibre organisation using multiscale simulations.
Current Opinion in Genetics & Development
(2026)
98
102464
(doi: 10.1016/j.gde.2026.102464)
The physical origin of ageing at biomolecular condensate interfaces
(2026)
(doi: 10.64898/2026.03.05.709844)
Electrostatic control of chromatin compaction safeguards against apoptotic DNA release
(2026)
(doi: 10.64898/2026.02.23.707452)
Condensate-Driven Transcriptional Reprogramming Defines Core Vulnerabilities in Esophageal and Gastric Cancers
(2026)
(doi: 10.64898/2026.02.23.707358)
Exploring Size-Controlled Exciton Evolution Using DNA Libraries
Journal of the American Chemical Society
(2026)
148
8893
(doi: 10.1021/jacs.5c21113)
Multi-scale simulations and cryo-ET structures of chromatin condensates rationalize phase separation
BIOPHYSICAL JOURNAL
(2026)
125
358a
A Goldilocks zone of DNA flexibility defines stable yet plastic nucleosomes, tuned by histone chemistry
(2026)
(doi: 10.64898/2026.02.16.706184)
Determination of Nucleotide–Nucleotide and Nucleotide–Amino Acid Binding Interactions from All-Atom Potential-of-Mean-Force Calculations
ACS Physical Chemistry Au
(2026)
6
308
Compositional Control of Aging Kinetics in TDP-43 Condensates
PRX Life
(2025)
3
043018
(doi: 10.1103/w7g3-6rsd)
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