Figuring out the rules: We are interested in discovering and developing new ways in which simple building blocks may be induced to self-assemble into complex structures. Our investigations currently focus upon the self-assembly of imine bonds around metal-ion templates, bringing both covalent C=N and coordinative N→Metal bonds into being during the same overall self-assembly process. The structures thus created can rearrange in well-defined ways at both covalent and coordinative linkages. Ongoing projects include:
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Container Molecules. The diamine and aldehyde shown above self-assemble with iron(II) in water to form a tetrahedral cage. This cage traps guest molecules within its cavity with high selectivity. The cage may be opened and the guest released using different triggers, one of which is a drop in pH. Applications in drug delivery are of interest, as are investigations of changes in the reactivity and behaviour of guest molecules upon encapsulation. |
Functional Materials. We have recently developed means to create metal-containing conjugated polymers through self-assembly. DFT calculations carried out by Laura Gagliardi and Christopher Cramer suggest that these might conduct electricity. Studies are thus being undertaken to investigate their properties. |
Protein-Like Objects. In collaboration with the groups of Ivan Huc and Sijbren Otto, we are examining the use of a dynamic self-assembly methodology to link foldamers together into protein- sized assemblies having well-defined tertiary structures. The functions of these objects may range from molecular recognition and catalysis to dynamic motion, as with their biological counterparts. |
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