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Professor Jonathan Nitschke

Portrait of jrn34

Figuring out the rules

We are interested in discovering and developing new ways in which simple building blocks may be induced to self-assemble into complex, functional structures. Our investigations currently focus upon the self-assembly of imine bonds around metal-ion templates, bringing both covalent C=N and coordinative N→Metal bonds into being during the same overall self-assembly process. The structures thus created can rearrange in well-defined ways at both covalent and coordinative linkages. Ongoing projects include:

 

Container Molecules. The diamine and aldehyde shown above self-assemble with iron(II) in water to form a tetrahedral cage. This cage traps guest molecules within its cavity with high selectivity. The cage may be opened and the guest released using different triggers, one of which is a drop in pH. Applications in drug delivery are of interest, as are investigations of changes in the reactivity and behaviour of guest molecules upon encapsulation.

 

Functional Materials. We have recently developed means to create metal-containing conjugated polymers through self-assembly. DFT calculations carried out by Laura Gagliardi and Christopher Cramer suggest that these might conduct electricity. Studies are thus being undertaken to investigate their properties.

Selected Publications

 

Feature Article: “Metal-organic container molecules through subcomponent self-assembly”, T.K. Ronson, S. Zarra, S.P. Black, J.R. Nitschke, Chem. Commun. 2013, 49, 2476-2490.

“Enantiopure Water-Soluble Fe4L6 Cages: Host-Guest Chemistry and Catalytic Activity”, Jeanne L. Bolliger, Ana M. Belenguer, and Jonathan R. Nitschke, Angew. Chem. Int. Ed. 2013, 52, 7958-7962.

“Aqueous Self-assembly of an Electroluminescent Double-helical Metallo-polymer”, X. de Hatten,  D. Asil, R.H. Friend, J.R. Nitschke,  J. Am. Chem. Soc. 2012, 135, 19170-19178.

“Anion-induced Reconstitution of a Self-assembling System to Express a Chloride-binding Co10L15 Pentagonal Prism”, I.A. Riddell, M.M.J. Smulders, J.K. Clegg, Y.R. Hristova, B. Breiner, J.D. Thoburn, J.R. Nitschke, Nature Chem. 2012, 51, 751-756.

 “White phosphorus is air-stable within a self-assembled tetrahedral capsule” P. Mal, B. Breiner, K. Rissanen and J.R. Nitschke, Science 2009, 324, 1697-1699.

“Systems chemistry: Molecular networks come of age” J.R. Nitschke, Nature 2009, 462, 736-738.

Publications

Directed Phase Transfer of an Fe(II)4L4 Cage and Encapsulated Cargo.
AB Grommet, JR Nitschke
– Journal of the American Chemical Society
(2017)
139,
2176
Separation and Selective Formation of Fullerene Adducts within an (M8L6)-L-II Cage
W Brenner, TK Ronson, JR Nitschke
– Journal of the American Chemical Society
(2017)
139,
75
Anion Recognition as a Supramolecular Switch of Cell Internalization.
J Rodríguez, J Mosquera, JR Couceiro, JR Nitschke, ME Vázquez, JL Mascareñas
– Journal of the American Chemical Society
(2017)
139,
55
Quantification of Stereochemical Communication in Metal-Organic Assemblies
AM Castilla, MA Miller, JR Nitschke, MMJ Smulders
– Angewandte Chemie (Weinheim an der Bergstrasse, Germany)
(2016)
128,
10774
Pathway-Dependent Post-assembly Modification of an Anthracene-Edged M<sup>II</sup><inf>4</inf>L<inf>6</inf> Tetrahedron
TK Ronson, BS Pilgrim, JR Nitschke
– Journal of the American Chemical Society
(2016)
138,
10417
That's No Moon: It's a Molecular Capsule
BS Pilgrim, JR Nitschke
– Chem
(2016)
1,
19
Inside Cover: Peripheral Templation Generates an M<sup>II</sup><inf>6</inf>L<inf>4</inf> Guest-Binding Capsule (Angew. Chem. Int. Ed. 28/2016)
FJ Rizzuto, WY Wu, TK Ronson, JR Nitschke
– Angewandte Chemie - International Edition
(2016)
55,
7866
Quantification of Stereochemical Communication in Metal-Organic Assemblies
AM Castilla, MA Miller, JR Nitschke, MMJ Smulders
– Angew Chem Int Ed Engl
(2016)
55,
10616
Subtle Ligand Modification Inverts Guest Binding Hierarchy in M II 8 L 6 Supramolecular Cubes
WJ Ramsay, FJ Rizzuto, TK Ronson, K Caprice, JR Nitschke
– Journal of the American Chemical Society
(2016)
138,
7264
Perfluorinated ligands induce meridional metal stereochemistry to generate M<inf>8</inf>L<inf>12</inf>, M<inf>10</inf>L<inf>15</inf>, and M<inf>12</inf>L<inf>18</inf> prisms
M Kieffer, BS Pilgrim, TK Ronson, DA Roberts, M Aleksanyan, JR Nitschke
– Journal of the American Chemical Society
(2016)
138,
6813
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Research Group

Research Interest Groups

Telephone number

01223 336324

Email address

jrn34@cam.ac.uk