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Professor Jonathan Nitschke

Portrait of jrn34

Figuring out the rules

We are interested in discovering and developing new ways in which simple building blocks may be induced to self-assemble into complex structures. Our investigations currently focus upon the self-assembly of imine bonds around metal-ion templates, bringing both covalent C=N and coordinative N→Metal bonds into being during the same overall self-assembly process. The structures thus created can rearrange in well-defined ways at both covalent and coordinative linkages. Ongoing projects include:

 

Container Molecules. The diamine and aldehyde shown above self-assemble with iron(II) in water to form a tetrahedral cage. This cage traps guest molecules within its cavity with high selectivity. The cage may be opened and the guest released using different triggers, one of which is a drop in pH. Applications in drug delivery are of interest, as are investigations of changes in the reactivity and behaviour of guest molecules upon encapsulation.

 

Functional Materials. We have recently developed means to create metal-containing conjugated polymers through self-assembly. DFT calculations carried out by Laura Gagliardi and Christopher Cramer suggest that these might conduct electricity. Studies are thus being undertaken to investigate their properties.

 

Protein-Like Objects. In collaboration with the groups of Ivan Huc and Sijbren Otto, we are examining the use of a dynamic self-assembly methodology to link foldamers together into protein- sized assemblies having well-defined tertiary structures. The functions of these objects may range from molecular recognition and catalysis to dynamic motion, as with their biological counterparts.

Selected Publications

 

Feature Article: “Metal-organic container molecules through subcomponent self-assembly”, T.K. Ronson, S. Zarra, S.P. Black, J.R. Nitschke, Chem. Commun. 2013, 49, 2476-2490.

“Enantiopure Water-Soluble Fe4L6 Cages: Host-Guest Chemistry and Catalytic Activity”, Jeanne L. Bolliger, Ana M. Belenguer, and Jonathan R. Nitschke, Angew. Chem. Int. Ed. 2013, 52, 7958-7962.

“Aqueous Self-assembly of an Electroluminescent Double-helical Metallo-polymer”, X. de Hatten,  D. Asil, R.H. Friend, J.R. Nitschke,  J. Am. Chem. Soc. 2012, 135, 19170-19178.

“Anion-induced Reconstitution of a Self-assembling System to Express a Chloride-binding Co10L15 Pentagonal Prism”, I.A. Riddell, M.M.J. Smulders, J.K. Clegg, Y.R. Hristova, B. Breiner, J.D. Thoburn, J.R. Nitschke, Nature Chem. 2012, 51, 751-756.

 “White phosphorus is air-stable within a self-assembled tetrahedral capsule” P. Mal, B. Breiner, K. Rissanen and J.R. Nitschke, Science 2009, 324, 1697-1699.

“Systems chemistry: Molecular networks come of age” J.R. Nitschke, Nature 2009, 462, 736-738.

Publications

Palladium-templated subcomponent self-assembly of macrocycles, catenanes, and rotaxanes
C Browne, TK Ronson, JR Nitschke – Angew Chem Int Ed Engl (2014) n/a
Molecular containers in complex chemical systems
S Zarra, DM Wood, DA Roberts, JR Nitschke – Chemical Society Reviews (2014)
Temperature- and Voltage-Induced Ligand Rearrangement of a Dynamic Electroluminescent Metallopolymer
D Asil, JA Foster, A Patra, X de Hatten, J Del Barrio, OA Scherman, JR Nitschke, RH Friend – Angew Chem Int Ed Engl (2014) 53, 8388
Cation- and anion-exchanges induce multiple distinct rearrangements within metallosupramolecular architectures.
IA Riddell, TK Ronson, JK Clegg, CS Wood, RA Bilbeisi, JR Nitschke – Journal of the American Chemical Society (2014) 136, 9491
Post-assembly Modification of Kinetically Metastable (Fe2L3)-L-II Triple Helicates
DA Roberts, AM Castilla, TK Ronson, JR Nitschke – Journal of the American Chemical Society (2014) 136, 8201
Two distinct allosteric active sites regulate guest binding within a Fe8Mo12 16+ cubic receptor
WJ Ramsay, JR Nitschke – Journal of the American Chemical Society (2014) 136, 7038
Stereochemistry in Subcomponent Self-Assembly
AM Castilla, WJ Ramsay, JR Nitschke – Accounts of Chemical Research (2014) 47, 2063
Predicting paramagnetic 1H NMR chemical shifts and state-energy separations in spin-crossover host-guest systems
WC Isley, S Zarra, RK Carlson, RA Bilbeisi, TK Ronson, JR Nitschke, L Gagliardi, CJ Cramer – Physical chemistry chemical physics : PCCP (2014) 16, 10620
Empirical and Theoretical Insights into the Structural Features and Host-Guest Chemistry of M8L4 Tube Architectures
W Meng, AB League, TK Ronson, JK Clegg, WC Isley, D Semrouni, L Gagliardi, CJ Cramer, JR Nitschke – Journal of the American Chemical Society (2014) 136, 3972
Fluorophore incorporation allows nanomolar guest sensing and white-light emission in M4L6 cage complexes
PP Neelakandan, A Jiménez, JR Nitschke – Chemical Science (2014) 5, 908
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Research Group

Research Interest Group

Telephone number

01223 336324

Email address

jrn34@cam.ac.uk