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Dr Gonçalo Bernardes

Portrait of gb453


Our research programme is at the interfaces of Chemistry and Biology. It aims at developing novel aqueous, chemoselective methods and their use for selective protein/ligand labelling in vitro and in vivo to understand and influence human disease. For further info on our research and for oportunities please check our research group website.



Tn Antigen Mimics Based on sp(2)-Iminosugars with Affinity for an anti-MUC1 Antibody.
EMS Fernández, CD Navo, N Martínez-Sáez, R Gonçalves-Pereira, VJ Somovilla, A Avenoza, JH Busto, GJL Bernardes, G Jiménez-Osés, F Corzana, JMG Fernández, CO Mellet, JM Peregrina
– Organic Letters
Urban Endocrine Disruptors Targeting Breast Cancer Proteins
D Montes-Grajales, GJ Bernardes, J Olivero-Verbel
– Chemical research in toxicology
Site-selective protein-modification chemistry for basic biology and drug development
N Krall, FP da Cruz, O Boutureira, GJ Bernardes
– Nature Chemistry
Iminoboronates are efficient intermediates for selective, rapid and reversible N-terminal cysteine functionalisation
H Faustino, MJSA Silva, LF Veiros, GJL Bernardes, PMP Gois
– Chem. Sci.
Construction of homogeneous antibody-drug conjugates using site-selective protein chemistry
P Akkapeddi, SA Azizi, AM Freedy, PMSD Cal, PMP Gois, GJL Bernardes
– Chem. Sci.
Enhancing Methotrexate Tolerance with Folate Tagged Liposomes in Arthritic Mice
E Nogueira, F Lager, D Le Roux, P Nogueira, J Freitas, C Charvet, G Renault, A Loureiro, CR Almeida, A Ohradanova-Repic, C Machacek, GJ Bernardes, A Moreira, H Stockinger, M Burnet, AM Carmo, AC Gomes, A Preto, G Bismuth, A Cavaco-Paulo
– Journal of Biomedical Nanotechnology
Sulfur-Limonene Polysulfide: A Material Synthesized Entirely from Industrial By-Products and Its Use in Removing Toxic Metals from Water and Soil
MP Crockett, AM Evans, MJH Worthington, IS Albuquerque, AD Slattery, CT Gibson, JA Campbell, DA Lewis, GJL Bernardes, JM Chalker
– Angew Chem Int Ed Engl
Peptide Anchor for Folate-Targeted Liposomal Delivery
E Nogueira, IC Mangialavori, A Loureiro, NG Azoia, MP Sárria, P Nogueira, J Freitas, J Härmark, U Shimanovich, A Rollett, G Lacroix, GJL Bernardes, G Guebitz, H Hebert, A Moreira, AM Carmo, JPFC Rossi, AC Gomes, A Preto, A Cavaco-Paulo
– Biomacromolecules
Deciphering the Non-Equivalence of Serine and Threonine O-Glycosylation Points: Implications for Molecular Recognition of the Tn Antigen by an anti-MUC1 Antibody
N Martínez-Sáez, J Castro-Lõpez, J Valero-González, D Madariaga, I Compañõn, VJ Somovilla, M Salvadõ, JL Asensio, J Jiménez-Barbero, A Avenoza, JH Busto, GJL Bernardes, JM Peregrina, R Hurtado-Guerrero, F Corzana
– Angewandte Chemie - International Edition
Size controlled protein nanoemulsions for active targeting of folate receptor positive cells
A Loureiro, E Nogueira, NG Azoia, MP Sárria, AS Abreu, U Shimanovich, A Rollett, J Härmark, H Hebert, G Guebitz, GJL Bernardes, A Preto, AC Gomes, A Cavaco-Paulo
– Colloids and surfaces. B, Biointerfaces
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Research Interest Groups

Telephone number

01223 336305

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